AI Article Synopsis
- Goblet cell carcinoma (GCC) is a rare appendiceal tumor that has both epithelial and neuroendocrine features, traditionally linked to neuroendocrine tumors but now considered more similar to adenocarcinomas.
- Recent studies highlight an unprecedented case of synchronous GCC of the appendix and colorectal adenocarcinoma of the cecum, marking a first in medical literature.
- The occurrence of these two tumors seems to be coincidental rather than causal, possibly explained by the "paracrine-effect theory," which suggests a local influence on tumor development.
Article Abstract
Goblet cell carcinoma (GCC) is a rare primary tumor of the appendix characterized by both epithelial and neuroendocrine components containing goblet cells. While in the past, the GCC has been associated with neuroendocrine tumors, recent studies consider that GCC is closer to adenocarcinoma than a neuroendocrine component. The association between gastro-intestinal (GI) carcinoids and second primary malignancies (SPMs) is widely described in the literature, but there is no reported case of GCC and synchronous adjacent adenocarcinoma of the colon. We describe the first case in the literature, to our knowledge, of synchronous colorectal adenocarcinoma of the cecum and GCC of the appendix that are incidentally discovered in the resected primary cancer specimen. The association between the two neoplasms seems to be not causal and maybe the "paracrine-effect theory" may explain the development of a second tumor close to the primary.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9590081 | PMC |
| http://dx.doi.org/10.3390/diseases10040077 | DOI Listing |
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