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Tailored biosynthesis of diosmin through reconstitution of the flavonoid pathway in .
Front Plant Sci
October 2024
Metabolic Engineering Division, National Institute of Agricultural Sciences, Rural Development Administration, Jeonju, Republic of Korea.
The flavonoid diosmin (diosmetin 7--rutinoside) is used as a therapeutic agent for disorders of the blood vessels such as hemorrhoids and varicose veins. Diosmin is commercially produced using semi-synthetic methods involving the oxidation of hesperidin, the most abundant flavonoid in citrus fruits. However, this method produces byproducts that are toxic to the environment, and new sustainable methods to produce diosmin are required.
View Article and Find Full Text PDFGenomic insights into the evolution of flavonoid biosynthesis and O-methyltransferase and glucosyltransferase in Chrysanthemum indicum.
Cell Rep
February 2024
Research Center of Chinese Herbal Resource Science and Engineering, Guangzhou University of Chinese Medicine, Guangzhou 510006, China; Key Laboratory of Chinese Medicinal Resource from Lingnan, Guangzhou University of Chinese Medicine, Guangzhou 510006, China; School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, China. Electronic address:
Flavonoids are a class of secondary metabolites widely distributed in plants. Regiospecific modification by methylation and glycosylation determines flavonoid diversity. A rare flavone glycoside, diosmin (luteolin-4'-methoxyl-7-O-glucosyl-rhamnoside), occurs in Chrysanthemum indicum.
View Article and Find Full Text PDFSystematic literature review and expert meeting report on health-related quality of life in chronic venous disease.
Int Angiol
December 2023
Department of Vascular Surgery, S. João University Hospital, Porto, Portugal.
Article Synopsis
- * A systematic review of studies on veno-active drugs (VADs) revealed that only specific treatments like micronized purified flavonoid fraction (MPFF), aminaphthone, and low-dose diosmin showed statistically significant improvements in HRQoL compared to placebo.
- * The research included data from various sources, highlighting a discrepancy between patient and physician perceptions regarding the impact of CVD, where physicians often underestimate the emotional and physical toll on patients.
Pyrethroids toxicity in vertebrates and invertebrates and amelioration by bioactive compounds: A review.
Pestic Biochem Physiol
November 2023
Department of Chemistry, International Hellenic University, Kavala GR-654 04, Greece.
Generations of different synthetic pesticides have been launched over time to maintain balance between production and consumption of the agricultural yield, control various disease programmes, store grains, etc. Pyrethroids, which are supposed to be non-toxic, have been excessively implemented and have contaminated soil and water bodies. Thus, pyrethroids cause severe and dreadful pernicious effects on various life forms residing in soil, air, and water.
View Article and Find Full Text PDFSystematic Engineering of Chassis for Efficient Flavonoid-7--Disaccharide Biosynthesis.
ACS Synth Biol
September 2023
Longping Branch, College of Biology, Hunan University, Changsha 410125, China.
Flavonoids are an essential class of secondary metabolites found in plants and possess various nutritional, medicinal, and agricultural properties. However, the poor water solubility of flavonoid aglycones limits their potential applications. To overcome this issue, glycosylation is a promising approach for improving water solubility and bioavailability.
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