A machine learning algorithm (MLA) has been applied to a Fourier transform infrared spectroscopy (FTIR) dataset previously analysed with a principal component analysis (PCA) linear discriminant analysis (LDA) model. This comparison has confirmed the robustness of FTIR as a prognostic tool for oral epithelial dysplasia (OED). The MLA is able to predict malignancy with a sensitivity of 84 ± 3% and a specificity of 79 ± 3%. It provides key wavenumbers that will be important for the development of devices that can be used for improved prognosis of OED.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9580266 | PMC |
| http://dx.doi.org/10.1088/2633-1357/ac95e2 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Aged garlic extract enhances the production of β‑defensin 4 via activation of the Wnt/β‑catenin pathway in mouse gingiva.
Exp Ther Med
February 2025
Central Research Institute, Wakunaga Pharmaceutical Co., Ltd., Akitakata, Hiroshima 739-1195, Japan.
Periodontal disease is recognized as a chronic multifactorial inflammatory condition initiated by dysbiosis within subgingival plaque biofilms. Antimicrobial peptides exhibit a wide spectrum of antimicrobial action, and thus, provide one of the first lines of host defense against oral pathogens. Aged garlic extract (AGE) is effective for preventing the progression of periodontal disease.
View Article and Find Full Text PDFOral cell lysates reduce osteoclastogenesis in murine bone marrow cultures.
Cytotechnology
February 2025
Department of Oral Biology, University Clinic of Dentistry, Medical University of Vienna, Sensengasse 2a, 1090 Vienna, Austria.
Mechanical and thermal cell damage can occur due to invasive procedures related to drilling, the insertion of dental implants, and periodontal treatments. Necrotic cells release the content of their cytoplasm and membrane fragments, thereby signaling the need for repair, which includes bone resorption by osteoclasts and inflammation. Here we screened lysates from human gingival fibroblasts, HSC2 and TR146 oral squamous carcinoma cell lines, as well as murine IDG-SW3 osteocytic and RAW264.
View Article and Find Full Text PDFCross-tissue comparison of epigenetic aging clocks in humans.
Aging Cell
January 2025
Department of Biobehavioral Health, Penn State University, University Park, Pennsylvania, USA.
Epigenetic clocks are a common group of tools used to measure biological aging-the progressive deterioration of cells, tissues, and organs. Epigenetic clocks have been trained almost exclusively using blood-based tissues, but there is growing interest in estimating epigenetic age using less-invasive oral-based tissues (i.e.
View Article and Find Full Text PDFYAP-driven malignant reprogramming of oral epithelial stem cells at single cell resolution.
Nat Commun
January 2025
Gleiberman Head and Neck Cancer Center, Moores Cancer Center, University of California San Diego Health, La Jolla, CA, 92037, USA.
Tumor initiation represents the first step in tumorigenesis during which normal progenitor cells undergo cell fate transition to cancer. Capturing this process as it occurs in vivo, however, remains elusive. Here we employ spatiotemporally controlled oncogene activation and tumor suppressor inhibition together with multiomics to unveil the processes underlying oral epithelial progenitor cell reprogramming into tumor initiating cells at single cell resolution.
View Article and Find Full Text PDFPreparation, antioxidant, antibacterial, and in vivo evaluation of pomegranate flower extract nanofibers based on thiolated chitosan and thiolated gelatin for treating aphthous stomatitis.
Carbohydr Polym
March 2025
Department of Pharmaceutics and Pharmaceutical Nanotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Protein Technology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:
Recurrent aphthous stomatitis (RAS) is a common condition that manifests as ulcerative lesions in the oral mucosa. In this study, bilayer, mucoadhesive nanofibers loaded with pomegranate flower extract (PFE) were prepared using thiolated gelatin (TGel) and thiolated chitosan (TCS) as the active layer and drug-free polycaprolactone (PCL) as the backing layer. Gelatin (Gel) and chitosan (CS) were successfully thiolated (proven by Ellman's assay, solubility, H NMR, FTIR, Raman spectroscopy, and XRD) and electrospun into active nanofibrous layers with a diameter of 356.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!