Methylation-Mediated Silencing of Promotes Breast Cancer Progression through PPAR and PI3K/AKT Pathway.

Retinoid-binding protein7 () is a member of the cellular retinol-binding protein (CRBP) family, which is involved in the pathogenesis of breast cancer. The study aims to illustrate the prognostic value and the potential regulatory mechanisms of expression in breast cancer. Bioinformatics analysis with the TCGA and CPTAC databases revealed that the mRNA and protein expression levels of in normal were higher compared to breast cancer tissues. Survival analysis displayed that the lower expression of the worse the prognosis in ER-positive (ER) breast cancer patients. Genomic analysis showed that low expression of correlates with its promoter hypermethylation in breast cancer. Functional enrichment analysis demonstrated that downregulation of expression may exert its biological influence on breast cancer through the PPAR pathway and the PI3K/AKT pathway. In summary, we identified as a novel biomarker that is helpful for the prognosis of ER breast cancer patients. Promoter methylation of is involved in its gene silencing in breast cancer, thus regulating the occurrence and development of ER breast cancer through the PPAR and PI3K/AKT pathways.