Almost everyone on the globe had to adjust to new conditions as a result of Covid-19 in conjunction with digitization. Contact and entry limitations damaged global business, trade and social connections. In addition, there is an increasing impact of digitization in supply chain. Regarding these disruptions current publications emphasize that global value chains are transforming to become more resilient. This study analyzes potential factors that might increase resilience in such a dynamic environment. The research is based on a quantitative empirical study to test the formulated hypotheses. The research questions were investigated trough a survey with logistics professionals. Two hypotheses were established as significant throughout the study. These are the robustness and responsiveness of global value chains, which have a substantial impact on their resilience. Both are determined direct or indirect by digital technologies. The complexity of global value chains had no discernible effect on the resilience of the system. A structural equation model is used to analyze the data's processing. This is achieved via a hypothesis model. As a result, major implications on global value chains' resilience can be found.
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http://dx.doi.org/10.1016/j.procs.2022.09.305 | DOI Listing |
J Paediatr Child Health
January 2025
WHO Collaborating Centre for Reference and Research on Influenza, VIDRL, Doherty Institute, Melbourne, Victoria, Australia.
Aims: Primary aim was to review severe acute respiratory infections (SARI) hospitalisations caused by respiratory syncytial virus (RSV) in children aged < 2 years in paediatric hospitals in Australia. Secondary aims included RSV subtyping, assessing RSV seasonality and contributing to the World Health Organisation's RSV surveillance programme.
Methods: We prospectively reviewed the medical records of children (< 2 years of age) with a confirmed SARI who were admitted to one of four major Australian paediatric hospitals and had a respiratory sample analysed by Polymerase Chain Reaction (PCR).
Sci Rep
January 2025
Department of Molecular Medicine, Biochemistry Unit, University of Pavia, Via Taramelli 3B, 27100, Pavia, Italy.
Perfluorinated compounds (PFAS) are well recognized toxic pollutants for humans, but if their effect is equally harmful for healthy and fragile people is unknown. Addressing this question represents a need for ensuring global health and wellbeing to all individuals in a world facing the progressive increase of aging and aging related diseases. This study aimed to evaluate the impact of perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA) and perfluorohexanoic acid (PFHxA) exposure on development and skeletal phenotype using the osteogenesis imperfecta (OI) zebrafish model Chihuahua (Chi/+), carrying a dominant glycine substitution in the α1 chain of collagen I and their wild-type (WT) littermates.
View Article and Find Full Text PDFJ Environ Manage
January 2025
Institute of Blue and Green Development, Shandong University, Weihai, 264209, China; Faculty of Finance, City University of Macau, Macao, China. Electronic address:
The impact of supply chain digitalization (SCD) on carbon dioxide emissions is an emerging area of research, particularly in China, which is the world's largest carbon emitter. This study uses micro-level data on listed companies from 2010 to 2021 to systematically verify the impact and mechanism of SCD on corporate carbon emissions (CCE) through the difference-in-differences model. We determined that SCD can significantly reduce CCE and its implementation path involves three aspects: promoting technological innovation, reducing financing constraints, and increasing market attention.
View Article and Find Full Text PDFOpen Life Sci
December 2024
State/National Key Laboratory of Biotherapy, Sichuan University, Chengdu, Sichuan, 610000, P. R. China.
In this study, we integrated transcriptomic and metabolomic analyses to achieve a comprehensive understanding of the underlying mechanisms of diabetic cardiomyopathy (DCM) in a diabetic rat model. Functional and molecular characterizations revealed significant cardiac injury, dysfunction, and ventricular remodeling in DCM. A thorough analysis of global changes in genes and metabolites showed that amino acid metabolism, especially the breakdown of branched-chain amino acids (BCAAs) such as valine, leucine, and isoleucine, is highly dysregulated.
View Article and Find Full Text PDFNeuromolecular Med
January 2025
Pharmacy College, Al-Farahidi University, Baghdad, Iraq.
The primary source of short-chain fatty acids (SCFAs), now recognized as critical mediators of host health, particularly in the context of neurobiology and cancer development, is the gut microbiota's fermentation of dietary fibers. Recent research highlights the complex influence of SCFAs, such as acetate, propionate, and butyrate, on brain cancer progression. These SCFAs impact immune modulation and the tumor microenvironment, particularly in brain tumors like glioma.
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