AI Article Synopsis
- Norfloxacin and ofloxacin are second-generation fluoroquinolone antibiotics that are hard to tell apart using traditional techniques due to their similar chemical structures.
- A new cocktail using terbium (Tb), europium (Eu), and cholate has been created to distinguish and quickly measure these drugs' concentrations when they are mixed.
- A gel-based paper sensor was developed to effectively detect and quantify these antibiotics individually, achieving a detection limit lower than 100 nM.
Article Abstract
Norfloxacin and ofloxacin are two frequently prescribed second-generation fluoroquinolone antibiotics with an identical 4-quinolone chromophore and hence, are difficult to distinguish by conventional methods (UV or fluorescence). We have designed a Tb/Eu/cholate cocktail that enabled us to differentiate these two drugs and rapidly measure their concentrations when present together. Additionally, a Tb-cholate gel-based paper sensor was developed to detect and quantify them in a single drug containing system with a limit of detection (LOD) well below 100 nM.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477015 | PMC |
| http://dx.doi.org/10.1039/d2ra03668a | DOI Listing |
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