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Advances in understanding and managing celiac disease: Pathophysiology and treatment strategies.
World J Gastroenterol
September 2024
Department of Burns, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China.
Article Synopsis
- The editorial discusses celiac disease (CeD), an autoimmune condition primarily affecting individuals with a genetic predisposition, characterized by gluten intolerance and symptoms like abdominal pain and diarrhea.* -
- Patients with CeD must adhere to a lifelong gluten-free diet, which can significantly impact their quality of life and financial well-being.* -
- The piece highlights the challenges in finding effective treatments due to the complex nature of CeD's pathogenesis and reviews both the disease's mechanisms and the current state of experimental and improved drug options.*
Commentary: Effect of gluten-free diet on autoimmune thyroiditis progression in patients with no symptoms or histology of celiac disease: a meta-analysis.
Front Endocrinol (Lausanne)
September 2024
Postgraduate Program in Evidence Based Medicine, Federal University of São Paulo, São Paulo, Brazil.
Digesting gluten with oral endopeptidases to improve the management of celiac disease.
World J Gastroenterol
July 2024
Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Iowa, Carver College of Medicine, and the Iowa City Veterans Affairs Medical Center, Iowa City, IA 52242, United States.
In our editorial, we want to comment on the article by Stefanolo titled "Effect of Aspergillus niger prolyl endopeptidase in patients with celiac disease on a long-term gluten-free diet". Celiac disease is an immune-mediated disorder triggered by dietary gluten in genetically predisposed individuals. Although avoiding gluten can permit patients to live symptom-free, ongoing voluntary or involuntary exposure to gluten is common and associated with persistent villous atrophy in small bowel mucosa.
View Article and Find Full Text PDFprolyl endopeptidase in celiac disease.
World J Gastroenterol
June 2024
Interdisciplinary Department of Medicine, Section of Microbiology and Virology, University of Bari "Aldo Moro", Bari 70124, Italy.
We comment here on the article by Stefanolo entitled "Effect of prolyl endopeptidase in patients with celiac disease on a long-term gluten-free diet", published in the . Celiac disease is a well-recognized systemic autoimmune disorder. In genetically susceptible people, the most evident damage is located in the small intestine, and is caused and worsened by the ingestion of gluten.
View Article and Find Full Text PDFObjective: Patients with coeliac disease (CD) need to follow a strict gluten-free diet to manage symptoms and prevent complications. Restrictions imposed by the diet can be challenging and affect quality of life (QoL). We explored sources of variation in QoL among patients with CD.
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