AI Article Synopsis
- Podocytes, which are specialized cells in the kidneys, change their shape and structure as they develop, stay healthy, age, or suffer injury.
- Measuring these structural changes quantitatively helps assess the health of the glomeruli, the filtering units of the kidneys.
- Different regions of the glomeruli respond uniquely to stressors like aging and high blood pressure, indicating that understanding these regional differences is important for diagnosing and treating kidney diseases.
Article Abstract
Podocytes undergo defined morphologic changes during development, homeostasis, and aging, and on injury. Quantitative podometric assessments of podocyte endowment provide a powerful tool to interrogate glomerular health. Expanding this approach to a regional assessment demonstrates that the podocytes from cortical, subcortical, and juxtamedullary glomeruli are not only morphologically heterogeneous per se, but respond differently to stressors, such as age and hypertension. This suggests that zonal glomerular changes harbor critical information to understand glomerulopathies.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.kint.2022.08.030 | DOI Listing |
Publication Analysis
Top Keywords
zoning podocytes
4
podocytes podocytes
4
podocytes undergo
4
undergo defined
4
defined morphologic
4
morphologic changes
4
changes development
4
development homeostasis
4
homeostasis aging
4
aging injury
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!