AI Article Synopsis
- The study investigates the role of dominant microflora in women with aerobic vaginitis (AV) in China, focusing on its potential for diagnostic use.
- High-throughput 16S rRNA sequencing was conducted to analyze the vaginal microbiota of AV patients, revealing increased levels of Streptococcus agalactiae and Streptococcus anginosus, along with a lack of Lactobacillus.
- The findings suggest that these bacterial characteristics, particularly the absence of Lactobacillus, are key indicators of AV, with implications for future clinical applications.
Article Abstract
Purpose: We aimed to explore the possible function of guiding dominant microflora for aerobic vaginitis (AV) women patients in China to know its diagnostic ability for the further clinical application.
Method: The characteristics and community compositions of AV vaginal microbiota was evaluated by high-throughput 16S ribosomal RNA (16S rRNA) sequencing after the vaginal microecology evaluations.
Results: The increased colonization of Streptococcus agalactiae and Streptococcus anginosus and the absence of Lactobacillus are typical manifestations of AV patients. In addition, Lactobacillus were the major correlated bacteria with control groups of Modified Donders' Score under 3. Most of the significant KEGG pathways were classified into metabolism pathway, where the two bacteria behaved their own metabolism characteristics.
Conclusion: The increased colonizations of Streptococcus agalactiae and Streptococcus anginosus and the absences of Lactobacillus are the typical manifestations of AV.
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| http://dx.doi.org/10.1016/j.diagmicrobio.2022.115806 | DOI Listing |
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