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Discontinuation and Reinitiation of Dual-Labeled GLP-1 Receptor Agonists Among US Adults With Overweight or Obesity.
JAMA Netw Open
January 2025
Healthcare Transformation Institute, Department of Medical Ethics and Health Policy, Perelman School of Medicine at the University of Pennsylvania, Philadelphia.
Importance: Adherence to glucagon-like peptide-1 receptor agonists (GLP-1 RAs) is important for their effectiveness. Discontinuation and reinitiation patterns are not well understood.
Objective: To describe rates of and factors associated with discontinuation and subsequent reinitiation of GLP-1 RAs among adults with overweight or obesity.
The effect of bedtime snacks on morning fasting blood glucose in gestational diabetes mellitus: a randomized controlled trial.
Acta Diabetol
January 2025
Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, No. 81 Meishan Road, Hefei, 230032, Anhui, China.
Importance: While guidelines recommend bedtime snacks for women with gestational diabetes mellitus (GDM), there is insufficient evidence championed those recommendation.
Objective: To evaluate if bedtime snacking is effective in preventing high fasting blood glucose incidence among women with GDM.
Design: An open-label, parallel-group, randomized controlled trial was conducted from December 2023 to July 2024 at Ma'anshan Maternal and Child Health Care Center, Anhui, China.
Targeted metabolomics reveals novel biomarkers for gestational diabetes mellitus.
Diabetes Obes Metab
January 2025
Nanjing Women and Children's Healthcare Institute, Women's Hospital of Nanjing Medical University, Nanjing Women and Children's Healthcare Hospital, Nanjing, China.
Aims: The utilization of targeted metabolomics technology promises to facilitate the identification of novel metabolic markers in women with gestational diabetes mellitus (GDM), which may in turn facilitate a more comprehensive investigation of the underlying mechanisms of gestational diabetes GDM.
Materials And Methods: In this study, we used targeted metabolomics to identify serum metabolites from women with or without GDM. The differential metabolites were categorized and analysed using pathway analyses, correlated with maternal glucose level, and assessed as predictors of GDM by receiver operating characteristics analysis.
Three-dimensional differences in plantar surface shape captured by methods used for custom accommodative insole design.
J Foot Ankle Res
March 2025
VA RR&D Center for Limb Loss and MoBility (CLiMB), VA Puget Sound Health Care System, Seattle, WA, USA.
Background: The patient-specific shape of custom accommodative insoles for individuals with diabetes provides full foot-to-insole contact, offloading areas with high plantar pressures and reducing ulceration risk. To design the insole surface, plantar surface shape is captured, traditionally with a foam crush box impression or more recently with 3D scans of the foot. Beyond discrete measurements of the foot, the overall plantar surface shapes obtained from these different methods have yet to be compared, however, differences in the shapes captured by these methods may affect the insole's surface geometry design and subsequent performance.
View Article and Find Full Text PDFThe Prevalence of Coronary Microvascular Dysfunction in Patients With Type 2 Diabetes Mellitus.
Catheter Cardiovasc Interv
January 2025
Section of Interventional Cardiology, MedStar Washington Hospital Center, Washington, District of Columbia, USA.
Patients with type 2 diabetes mellitus (DM) are more susceptible to microvascular complications. However, whether DM is associated with coronary microvascular dysfunction (CMD) is unclear. This observational study used data from the Coronary Microvascular Disease Registry (CMDR) (NCT05960474) and included patients with angina and no obstructive coronary artery disease (ANOCA) who underwent invasive CMD evaluation using the CoroVentis CoroFlow System (Abbott Vascular, Santa Clara, CA).
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