Getting the clock back on its feet: targeting the circadian clock to treat osteoarthritis.

Growing evidence suggests that circadian clock dysfunction may contribute to the pathology of osteoarthritis. In this issue, He et al. use in vivo and human-derived osteoarthritis models to demonstrate the therapeutic potential of pharmacologically manipulating components of the cartilage circadian clock. In doing so, the authors provide an important proof-of-principle supporting circadian clock-targeted therapy as a treatment option for osteoarthritis. Comment on: https://doi.org/10.1111/febs.16601.