Attention deficit hyperactivity disorder (ADHD) is one of the most prevalent neurodevelopmental disorders, characterized by specific cognitive and behavioral symptoms. A fronto-cerebellar circuit is implicated in ADHD, and despite its role in cognitive/behavioral aspects, the neurochemical alterations in this circuit are not well understood. The present study aimed to compare neurometabolite ratios of the fronto-cerebellar circuit between ADHD and control participants, using proton magnetic resonance spectroscopy (H MRS), and investigate whether neurometabolites related to cognitive/behavioral characteristics. Fifteen children and adolescents with ADHD and 19 healthy control participants were enrolled in this study. Two single voxel spectra localized in the right dorsolateral prefrontal cortex (DLPFC) and left Crus 1 were taken using PRESS sequence. Also, neuropsychological performance and behavioral characteristics were evaluated. Results revealed that ADHD group had different choline/creatine and glutamate/creatine ratios in the fronto-cerebellar circuit, compared to healthy controls. The current study also found significant correlations between neurometabolite ratios in the both region of interests (ROIs) and cognitive/behavioral characteristics. These results suggest that alterations in fronto-cerebellar metabolites may be related to cognitive and behavioral deficits in ADHD, and also, our findings highlight that the cerebellum may be involved in the pathophysiology of ADHD.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ijpsycho.2022.10.005 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effect of Artificial Intelligence Helpfulness and Uncertainty on Cognitive Interactions with Pharmacists: Randomized Controlled Trial.
J Med Internet Res
January 2025
Department of Clinical Pharmacy, College of Pharmacy, University of Michigan, Ann Arbor, MI, United States.
Background: Clinical decision support systems leveraging artificial intelligence (AI) are increasingly integrated into health care practices, including pharmacy medication verification. Communicating uncertainty in an AI prediction is viewed as an important mechanism for boosting human collaboration and trust. Yet, little is known about the effects on human cognition as a result of interacting with such types of AI advice.
View Article and Find Full Text PDFInvestigating the Efficacy of the Web-Based Common Elements Toolbox (COMET) Single-Session Interventions in Improving UK University Student Well-Being: Randomized Controlled Trial.
J Med Internet Res
January 2025
Department of Psychology, University of Bath, Bath, United Kingdom.
Background: Mental health problems in university students are associated with many negative outcomes, yet there is a gap between need and timely access to help. Single-session interventions (SSIs) are designed to be scalable and accessible, delivering core evidence-based intervention components within a one-off encounter.
Objective: COMET (Common Elements Toolbox) is an online self-help SSI that includes behavioral activation, cognitive restructuring, gratitude, and self-compassion.
Effectiveness of psychological interventions in reducing post-traumatic stress among post-myocardial infarction patients: a systematic review and meta-analysis.
Eur J Cardiovasc Nurs
January 2025
Alice Lee Centre for Nursing Studies, Yong Loo Lin School of Medicine, National University of Singapore, Level 5, Centre for Translational Medicine, Block MD 6, 14 Medical Drive, Singapore 117599, Singapore.
Aims: Myocardial infarction (MI) can lead to post-traumatic stress disorder (PTSD) which frequently occurs with anxiety and depression, impairing daily functioning and increasing the risk of recurrent cardiovascular events. While psychological interventions have shown promise in reducing anxiety and depression, their effectiveness for PTSD in post-MI patients remains unexplored. This systematic review and meta-analysis aim to evaluate the effectiveness of psychological interventions on PTSD, anxiety, and depression in post-MI patients.
View Article and Find Full Text PDFCharacteristic Structure of the Relationships Among Depression, Maladaptive Cognition, and Internet Addiction and Its Temporal Evolution in University Students: A Network Analysis.
Stress Health
February 2025
Collaborative Innovation Center of Assessment Toward Basic Education Quality, Beijing Normal University, Beijing, China.
This study explored the structure and temporal evolution of the relationship among depression, maladaptive cognition, and internet addiction (DMI) among university students by focusing on topological and dynamic properties in a network analysis. A 3-year longitudinal survey was conducted with 873 university students (M = 18.32, SD = 0.
View Article and Find Full Text PDFBehavioural and psychological symptoms of people with dementia in acute hospital settings: a systematic review and meta-analysis.
Age Ageing
January 2025
Centre for Psychiatry and Mental Health, Wolfson Institute of Population Health, Queen Mary University of London, London, E13 8SP, United Kingdom of Great Britain and Northern Ireland.
Background: Behavioural and psychological symptoms of dementia (BPSD) can complicate acute hospital care, but evidence on BPSD in this setting is heterogeneous.
Objective: To determine the prevalence of BPSD in acute hospitals and explore related risk factors, treatments, and outcomes (PROSPERO: CRD42023406294).
Methods: We conducted a systematic review and meta-analysis by searching Cochrane Library, MEDLINE, and PsycINFO for studies on BPSD prevalence among older people with dementia during their acute hospital admissions (up to 5 March 2024).
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!