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| http://dx.doi.org/10.1073/pnas.2216019119 | DOI Listing |
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Baolier Capsule's Secret Weapon: Piperine Boosts Cholesterol Excretion to Combat Atherosclerosis.
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Department of Cardiology, The Seventh Affiliated Hospital of Southern Medical University, Southern Medical University, Foshan, 528244, People's Republic of China.
Purpose: The Baolier capsule (BLEC) is a proprietary Mongolian medicine administered for treating hypercholesterolemia and atherosclerosis (AS). However, the therapeutic effects, primary bioactive ingredients, and potential mechanisms underlying hypercholesterolemia and AS remain unclear. This study aimed to investigate the pharmacological effects, principal active ingredients, and mechanisms of BLEC against hypercholesterolemia and AS.
View Article and Find Full Text PDFExploring the efficacy of Wenshentiaojing decoction in PCOS: Network pharmacology and mouse model insights.
Bioorg Chem
January 2025
Department of Physiology, School of Basic Medical Sciences, Xuzhou Medical University, Xuzhou, Jiangsu Province 221009, PR China; National Experimental Teaching Demonstration Center for Basic Medicine, Xuzhou Medical University, Xuzhou, Jiangsu Province 221009, PR China. Electronic address:
Background: Wenshentiaojing Decoction (WSTJD), a traditional Chinese herbal prescription, was first recorded in the "Ye Tianshi female department secret recipe for diagnosis and treatment ". It has been proven effective in treating polycystic ovary syndrome (PCOS). However, the active ingredients and molecular mechanism of WSTJD against PCOS remain unclear.
View Article and Find Full Text PDFIdentifying potential active ingredients from pomegranate in treating anemia: CPA3 and SOX4 are key proteins.
Int J Biol Macromol
January 2025
School of Pharmacy, Hubei University of Chinese Medicine, Wuhan, Hubei 430065, China. Electronic address:
Unlabelled: Fanconi anemia is a rare hereditary blood disorder that usually manifests as bone marrow failure, dysplasia, cancer susceptibility and anemia. Pomegranate, as a "secret" for people in Xinjiang, China and India, is commonly used for treating different types of anemia.
Objective: This study aimed to identify potential proteins of FA and to discover potential drugs from pomegranates.
Non-target screening reveals 124 PFAS at an AFFF-impacted field site in Germany specified by novel systematic terminology.
Anal Bioanal Chem
October 2024
Environmental Analytical Chemistry, Department of Geosciences, University of Tübingen, Schnarrenbergstraße 94-96, 72076, Tübingen, Germany.
Article Synopsis
- A major fire incident in Reilingen, Germany, in 2008 resulted in the release of AFFF ingredients, causing significant soil and groundwater contamination due to the hidden nature of the surfactants used.
- The study used an advanced extraction method with liquid chromatography to identify 124 different per- and polyfluoroalkyl substances (PFAS) in the contaminated soil, including 9 PFAS subclasses detected for the first time.
- To improve clarity and consistency in communication regarding AFFF-related PFAS, the research introduced new terminology to help identify and categorize these compounds effectively.
Constructing the cGAMP-Aluminum Nanoparticles as a Vaccine Adjuvant-Delivery System (VADS) for Developing the Efficient Pulmonary COVID-19 Subunit Vaccines.
Adv Healthc Mater
December 2024
School of Pharmacy, Anhui Medical University, 81 Plum Hill Road, Hefei, Anhui Province, 230032, China.
The cGAMP-aluminum nanoparticles (CAN) are engineered as a vaccine adjuvant-delivery system to carry mixed RBD (receptor-binding domain) of the original severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its new variant for developing bivalent pulmonary coronavirus disease 2019 (COVID-19) vaccines (biRBD-CAN). High phosphophilicity/adsorptivity made intrapulmonary CAN instantly form the pulmonary ingredient-coated CAN (piCAN) to possess biomimetic features enhancing biocompatibility. In vitro biRBD-CAN sparked APCs (antigen-presenting cells) to mature and make extra reactive oxygen species, engendered lysosome escape effects and enhanced proteasome activities.
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