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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10037477 | PMC |
| http://dx.doi.org/10.1164/rccm.202210-1925ED | DOI Listing |
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Department of General Surgery, The Second Clinical Medical School, The Second Hospital of Lanzhou University, Lanzhou University, Lanzhou, Gansu, 730000, China.
Background: Tumor-associated macrophages (TAMs), particularly M2-polarized TAMs, are significant contributors to tumor progression, immune evasion, and therapy resistance in gastric cancer (GC). Despite efforts to target TAM recruitment or depletion, clinical efficacy remains limited. Consequently, the identification of targets that specifically inhibit or reprogram M2-polarized TAMs presents a promising therapeutic strategy.
View Article and Find Full Text PDFBackground: Fibroinflammatory cholangiopathies, such as primary sclerosing cholangitis (PSC) and primary biliary cholangitis (PBC), are characterized by inflammation and biliary fibrosis, driving disease-related complications. In biliary fibrosis, cholangiocytes activated by transforming growth factor-β (TGFβ) release signals that recruit immune cells to drive inflammation and activate hepatic myofibroblasts to deposit the extracellular matrix (ECM). TGFβ regulates stearoyl-CoA desaturase (SCD), an enzyme that catalyzes the synthesis of monounsaturated fatty acids, in stimulating fibroinflammatory lipid signaling.
View Article and Find Full Text PDFMulti-modal analysis of human hepatic stellate cells identifies novel therapeutic targets for metabolic dysfunction-associated steatotic liver disease.
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Department of Surgery, University of California San Diego, La Jolla, California, USA. Electronic address:
Background & Aims: Metabolic dysfunction-associated steatotic liver disease ranges from metabolic dysfunction-associated steatotic liver (MASL) to metabolic dysfunction-associated steatohepatitis (MASH) with fibrosis. Transdifferentiation of hepatic stellate cells (HSCs) into fibrogenic myofibroblasts plays a critical role in the pathogenesis of MASH liver fibrosis. We compared transcriptome and chromatin accessibility of human HSCs from NORMAL, MASL, and MASH livers at single-cell resolution.
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View Article and Find Full Text PDFOral squamous cell carcinomas drive monocytes into immunosuppressive CD25CD163CD206 macrophages.
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Department of Immunology, Ophthalmology and ORL, School of Medicine, Complutense University of Madrid, Pza Ramon y Cajal, s/n, 28040 Madrid, Spain. Electronic address:
Article Synopsis
- Tumor-associated macrophages (TAMs) play a significant role in the tumor microenvironment of oral squamous cell carcinomas (OSCCs) and primarily originate from circulating monocytes that differentiate locally.
- Research showed that cell culture media from OSCC cell lines, H413 and TR146, encourages monocytes to become M2 macrophages, which are characterized by high CD163 and CD206 expression and low levels of activation markers.
- Additionally, the study identified specific soluble proteins in the media that promote this differentiation and linked it to an immunosuppressive profile that hinders T cell activation, shedding light on how OSCCs support tumor growth by altering immune cell behavior.
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