Introduction: Anti NMDAR encephalitis is a neuropsychiatric syndromic disease caused by an immunological response. Acute behavioral changes, psychosis, and catatonia are common clinical manifestations, are seizures, amnesia, speech difficulties, dyskinesia, and autonomic dysregulation.
Case Presentation: We discuss the case of a 14-year-old girl who had psychotic symptoms and tested positive for anti-NMDAR antibodies.
Discussion: Patients present with psychiatric symptoms such as delusions, hallucinations, agitation, changes in speech mania, disorganized thinking, catatonia, insomnia, and often seizures. Anti-NMDAR encephalitis should be suspected in teenage patient with acute psychotic symptoms and seizure episodes. A multidisciplinary treatment strategy is required.
Conclusion: The delayed treatment can lead to complications and delayed recovery complicating the disease process so multidisciplinary approach of treatment is necessary.
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http://dx.doi.org/10.1016/j.amsu.2022.104790 | DOI Listing |
Alzheimers Dement
December 2024
The University of British Columbia, Vancouver, BC, Canada.
Background: Limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) is a pathological process diagnosed at autopsy, involving deposition of TDP-43 in the medial temporal lobes. The name LATE-NC was recently proposed to represent the pathological process, while "LATE" has been suggested to represent the clinical syndrome. However, there are currently no available criteria to diagnose this syndrome during life, and the clinical phenotype is not well understood.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhi, Delhi, India.
Background: Neuropsychiatric symptoms (NPS) are common in patients who develop dementia before the age of 65 years, defined as early-onset dementia (EoD). NPS are a major source of morbidity and caregiver distress in patients living with EoD. The prevalence, severity and types of NPS in different populations are unclear.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Queen Mary University of London, London, United Kingdom.
Background: Dementia is associated with a range of non-cognitive features that can occur during the prodromal phase. Improved recognition of non-cognitive presentations of dementia could reduce inequalities in dementia diagnosis, particularly if sociocultural factors influence rates of help-seeking for cognitive symptoms. We aimed to investigate presentations to primary care in the years before dementia diagnosis in a deprived and ethnically diverse population with universal access to health care.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Queen Mary University of London, London, United Kingdom.
Background: Alzheimer's disease (AD) is associated with a range of non-cognitive symptoms that can be early or even presenting features. Better recognition of pre-diagnostic symptoms of AD would support improved early detection and diagnosis.
Method: To identify possible prodromal symptoms of AD, we systematically searched three electronic databases for prospective longitudinal studies to March 2023, that reported the risk of AD diagnosis associated with non-cognitive symptoms.
Alzheimers Dement
December 2024
University of Exeter, Exeter, United Kingdom.
Background: When assessed in the Mild Behavioral Impairment (MBI) framework, late-life onset psychotic like symptoms (MBI-psychosis) are associated with incident cognitive decline and dementia. One approach to examining the genetic basis of this association, is to use Polygenic Risk Scores (PRS) to determine whether genetic propensity for late-life onset psychosis is shared with other traits. We aimed to elucidate the shared genetic liability between Educational Attainment, Intelligence, Reasoning, Memory, Neuroticism, Alzheimer's Disease, Major Depression, Schizophrenia and Bipolar Disorder and Mild Behavioral Impairment (MBI)-Psychosis in later life.
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