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| http://dx.doi.org/10.3389/fmed.2022.1004029 | DOI Listing |
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The D-lactate enigma: exploring the inflammatory influence of D-lactate in cattle.
Front Vet Sci
December 2024
Laboratory of Inflammation Pharmacology and Immunometabolism, Institute of Pharmacology and Morphophysiology, Faculty of Veterinary Sciences, Universidad Austral de Chile, Valdivia, Chile.
D-lactic acidosis is associated with fermentative disturbances and is often marked by elevated levels of D-lactic acid in the blood, ruminal fluid, and synovial fluid in cattle. D-lactic acidosis is linked to various inflammatory manifestations, and although the causative factors have been extensively explored, the exact pathogenesis of the associated inflammation remains elusive. Notably, less attention has been given to D-lactate, a stereoisomer found in the plasma of affected animals, which may lead to D-lactic acidosis.
View Article and Find Full Text PDFEditorial Commentary: Anterior Cruciate Ligament Repair Could Be Indicated in Older, Less Active Patients.
Arthroscopy
December 2024
Mass General Brigham Sports Medicine.
Anterior cruciate ligament (ACL) injuries do not heal anatomically on their own and often lead to post-traumatic osteoarthritis (PTOA). ACL reconstruction, though effective, can contribute to PTOA, and donor site morbidity remains a concern with autografts. While ACL repair has traditionally shown poorer outcomes (27% failure rate in the 1990s and early 2000s), a recent review of newer techniques shows promising results and no significant differences in patient-reported outcomes between repair and reconstruction.
View Article and Find Full Text PDFEvaluating the Diagnostic Utility of Serum Laboratory Studies and Synovial Fluid Analysis in Identifying Periprosthetic Joint Infection in Metal Hip Revisions.
Cureus
October 2024
Orthopedic Surgery, Anne Arundel Medical Center, Annapolis, USA.
Background Metal-on-metal (MoM) bearing surfaces have been implicated as a cause of increased complication rates in total hip arthroplasty (THA), with local and systemic reactions identified. These reactions may cause abnormal laboratory results in common tests that are used to diagnose periprosthetic joint infection (PJI). The purpose of this study was to evaluate the utility of common laboratory studies in the diagnosis of PJI in patients undergoing revision THA with MoM bearings.
View Article and Find Full Text PDFEnhanced joint pain in diabetic patients with knee osteoarthritis is associated with increased synovitis, synovial immune cell infiltration, and erythrocyte extravasation.
Front Endocrinol (Lausanne)
October 2024
Institute of Physiology 1/Neurophysiology, Jena University Hospital, Friedrich Schiller University, Jena, Germany.
Objective: Diabetes mellitus (DM) is an important risk factor for the development of osteoarthritis (OA), increasing OA progression and OA pain. To gain insight into the underlying mechanisms of how DM exacerbates OA processes and OA pain, this study analyzed histological differences of synovial tissues from non-DM and DM patients with OA and correlated these differences with knee pain severity.
Materials And Methods: Synovial tissue was obtained from 12 non-DM and 10 DM patients with advanced knee OA who underwent total knee arthroplasty.
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