AI Article Synopsis
- The review focuses on microgravity's effects on fibroblast functions crucial for wound healing (WH), particularly in the context of spaceflight.
- Studying how microgravity alters fibroblast behavior can inform not only astronaut safety but also enhance WH management on Earth.
- The authors suggest that fibroblasts exposed to microgravity could serve as models for understanding WH impairment on our planet, highlighting the need for further research in this area.
Article Abstract
Wound healing (WH) and the role fibroblasts play in the process, as well as healing impairment and fibroblast dysfunction, have been thoroughly reviewed by other authors. We treat these topics briefly, with the only aim of contextualizing the true focus of this review, namely, the microgravity-induced changes in fibroblast functions involved in WH. Microgravity is a condition typical of spaceflight. Studying its possible effects on fibroblasts and WH is useful not only for the safety of astronauts who will face future interplanetary space missions, but also to help improve the management of WH impairment on Earth. The interesting similarity between microgravity-induced alterations of fibroblast behavior and fibroblast dysfunction in WH impairment on Earth is highlighted. The possibility of using microgravity-exposed fibroblasts and WH in space as models of healing impairment on Earth is suggested. The gaps in knowledge on fibroblast functions in WH are analyzed. The contribution that studies on fibroblast behavior in weightlessness can make to fill these gaps and, consequently, improve therapeutic strategies is considered.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9578548 | PMC |
| http://dx.doi.org/10.3389/fbioe.2022.958381 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Brainstem and midbrain structures involved in memory encoding in healthy aging and mild cognitive impairment, a 3T task‐fMRI study.
Alzheimers Dement
December 2024
German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany
Background: Memory decline, which is especially prevalent in Alzheimer’s disease (AD), has been studied via fMRI, primarily focusing on the prefrontal cortex and hippocampus. However, emerging evidence suggests that the brainstem, alongside various midbrain regions, is an initial target for pathological processes like hyperphosphorylated TAU protein accumulation. Among these, the locus coeruleus, a noradrenergic nucleus in the pons, projects to critical midbrain areas supporting memory encoding.
View Article and Find Full Text PDFComprehensive review of phthalate exposure: Health implications, biomarker detection and regulatory standards.
J Steroid Biochem Mol Biol
December 2024
Department of Applied Chemistry and Chemical Engineering, Islamic University, Kushtia 7003, Bangladesh; Institute of Glass and Ceramic Research and Testing (IGCRT), Bangladesh Council of Scientific and Industrial Research (BCSIR), Dhaka 1205, Bangladesh.
Phthalates are a wide family of chemicals that are used in many different industrial applications used in many different industrial applications, including the production of plastics, toys, food packaging particularly for kids, and medical equipment. Due to their various chemical and physical properties, phthalates may negatively impact humans, animals, and the environment. Thus the potential for phthalate exposure and harm to humans, animals, and the environment is high because its presence is alarming.
View Article and Find Full Text PDFHigh correlated color temperature white light-emitting diodes disrupt refractive development in guinea pigs.
Heliyon
November 2024
Department of Ophthalmology, The Second Hospital of Jilin University, Changchun, China.
Ubiquitous white light-emitting diodes (LEDs) possess optical properties that differ from those of natural light. This difference can impact visual perception and biological functions, thus potentially affecting eye health. Myopia, which leads to visual impairments and potentially irreversible vision loss or blindness, is the most prevalent refractive error worldwide.
View Article and Find Full Text PDFTCA cycle impairment leads to PIN2 internalization and degradation via reduced MAB4 level and ARA6 components in Arabidopsis roots.
Front Plant Sci
December 2024
College of Life Sciences, Fujian Agriculture and Forestry University, Fujian, China.
The mitochondrial pyruvate dehydrogenase complex (PDC) plays a crucial role in linking the glycolysis pathway and the tricarboxylic acid (TCA) cycle. Previously, we reported that a mutation of , encoding an E1β subunit of PDC, affects the abundance of auxin efflux carriers PIN-FORMED proteins (PINs) via reduced recycling and enhanced degradation in vacuoles. Here, we further analyzed the effects of TCA cycle inhibition on vesicle trafficking using both the mutant and 3-BP, a TCA cycle inhibitor.
View Article and Find Full Text PDFSilent threats of lead-based paints in toys and households to children's health and development.
J Hazard Mater
December 2024
Consortium on Health, Environment, Education, and Research (CHEER), The Education University of Hong Kong, Tai Po, Hong Kong. Electronic address:
Lead (Pb), a highly toxic heavy metal, poses a significant global health risk, particularly to children. Widely used in paint manufacturing for its remarkable corrosion-resistance properties Pb exposure has been linked to severe health issues, including reduced neurotransmitter levels, organ damage, potentially leading to death in extreme cases. Children Are particularly vulnerable, with Pb toxicity primarily affecting the brain, reproductive, kidneys, and cardiovascular systems.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!