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A high-valence bismuth(V) nanoplatform triggers cancer cell death and anti-tumor immune responses with exogenous excitation-free endogenous HO- and O-independent ROS generation.
Nat Commun
January 2025
State Key Lab of Metal Matrix Composites School of Materials Science and Engineering Shanghai Jiao Tong University 800 Dongchuan Road, Shanghai, P. R. China.
Reactive oxygen species with evoked immunotherapy holds tremendous promise for cancer treatment but has limitations due to its dependence on exogenous excitation and/or endogenous HO and O. Here we report a versatile oxidizing pentavalent bismuth(V) nanoplatform (NaBiO-PEG) can generate reactive oxygen species in an excitation-free and HO- and O-independent manner. Upon exposure to the tumor microenvironment, NaBiO-PEG undergoes continuous H-accelerated hydrolysis with •OH and O generation through electron transfer-mediated Bi-to-Bi conversion and lattice oxygen transformation.
View Article and Find Full Text PDFEmerging Radiotherapy Technologies for Head and Neck Squamous Cell Carcinoma: Challenges and Opportunities in the Era of Immunotherapy.
Cancers (Basel)
December 2024
Department of Radiation Oncology, University of North Carolina, Chapel Hill, NC 27599, USA.
Radiotherapy (RT) is an integral component in the multidisciplinary management of patients with head and neck squamous cell carcinoma (HNSCC). Significant advances have been made toward optimizing tumor control and toxicity profiles of RT for HNSCC in the past two decades. The development of intensity modulated radiotherapy (IMRT) and concurrent chemotherapy established the standard of care for most patients with locally advanced HNSCC around the turn of the century.
View Article and Find Full Text PDFHighs and Lows of Spatially Fractionated Radiation Therapy: Dosimetry and Clinical Outcomes.
Pract Radiat Oncol
December 2024
Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota.
Objectives: Spatially fractionated radiation therapy (SFRT) intentionally delivers a heterogeneous dose distribution characterized by alternating regions of high and low doses throughout a tumor. This modality may enhance response to subsequent whole tumor radiation in bulky and radioresistant lesions that are historically less responsive to conventional radiation doses alone. The current study presents a single institution experience with modern era SFRT using predominantly a volumetric modulated arc therapy (VMAT) lattice technique.
View Article and Find Full Text PDFEnhancing Magnetic Hyperthermia Efficiency in Pd/Fe-Oxide Hybrid Nanoparticles through Mn-Doping.
ACS Appl Nano Mater
December 2024
Department of Biotechnology, Delft University of Technology, 2628 HZ Delft, The Netherlands.
Multifunctional, biocompatible magnetic materials, such as iron oxide nanoparticles (IONPs), hold great potential for biomedical applications including diagnostics (e.g., MRI) and cancer therapy.
View Article and Find Full Text PDFComparative Analysis of Dose Gradients and Valley Doses in Pelvic Lattice Radiotherapy in RapidArc and IMRT.
Asian Pac J Cancer Prev
November 2024
School of Advanced Sciences, Vellore Institute of Technology, Vellore, India.
Purpose: This study evaluated the dose fall off and valley dose percentage in pelvic cancer Lattice Radiotherapy (LRT) using various treatment techniques.
Methods: Forty five treatment plans were developed for 15 patients undergoing radiotherapy using a linear accelerator. Plans were categorized into three sets: RapidArc (RA), seven-field intensity-modulated radiation therapy (IMRT), and nine-field IMRT, both for high-dose (HD) vertices and the entire planning target volume (PTV).
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