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Impact of polypharmacy on clinical outcomes in patients with advanced heart failure undergoing cardiac resynchronization therapy.
J Arrhythm
February 2025
Department of Cardiology and Clinical Examination, Faculty of Medicine Oita University Yufu Oita Japan.
Background: The prevalence rates of heart failure (HF) and hyperpolypharmacy have increased with the aging population. While a negative impact of hyperpolypharmacy on HF clinical outcomes has already been reported, the effects of hyperpolypharmacy on patients with advanced HF with reduced ejection fraction (HFrEF) undergoing cardiac resynchronization therapy (CRT) remain unclear.
Methods: We retrospectively evaluated data from 147 patients with advanced HFrEF who underwent CRT between March 2004 and June 2020.
Targeting KAT7 inhibits the progression of colorectal cancer.
Theranostics
January 2025
Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, China.
Colorectal cancer (CRC) is a leading cause of cancer-related mortality. Epigenetic modifications play a significant role in the progression of CRC. KAT7, a histone acetyltransferase, has an unclear role in CRC.
View Article and Find Full Text PDFAssessing Avascular Necrosis Risk and Outcomes After Open Reduction for Developmental Dysplasia of the Hip in Children.
Cureus
December 2024
General Surgery, Prince Sultan Military Medical City, Riyadh, SAU.
Background Avascular necrosis (AVN) of the femoral head is a serious complication after surgical treatment of developmental dysplasia of the hip (DDH). The main objective of this study is to identify the incidence of AVN and to define AVN risk factors. The study also aims to identify the effects of AVN and other factors on final clinical and radiological outcomes.
View Article and Find Full Text PDFClinicopathologic features and prognosis of incidental prostate cancer after radical cysto-prostatectomy: a comparative study between China and the West.
Transl Androl Urol
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Department of Urology & The Institute of Applied Lithotripsy Technology, Peking University People's Hospital, Beijing, China.
Background: Bladder cancer (BCa) is one of the most common tumors of the urinary system, imposing a significant societal burden. BCa is categorized into muscle-invasive BCa (MIBC) and non-MIBC (NMIBC) types. Radical cystoprostatectomy (RCP) is the standard treatment for MIBC and refractory NMIBC, but it can lead to serious side effects.
View Article and Find Full Text PDFAre we disadvantaging smokers by excluding them from kidney transplantation? A single-centre experience and survey of kidney transplantation units.
Intern Med J
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Nephrology and Transplantation Department, John Hunter Hospital, Newcastle, New South Wales, Australia.
Background: Smoking has been shown to have detrimental effects on KT outcomes and survival. Most units and guidelines advocate for the cessation of smoking prior to a kidney transplant and consider it a general contraindication to listing. Smoking prevalence is higher in disadvantaged groups.
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