Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1183/13993003.00417-2022 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
3D bioprinting of the airways and lungs for applications in tissue engineering and in vitro models.
J Tissue Eng
December 2024
Department of Thoracic Surgery, The Second Affiliated Hospital, Air Force Medical University, Xi'an, People's Republic of China.
Tissue engineering and in vitro modeling of the airways and lungs in the respiratory system are of substantial research and clinical importance. In vitro airway and lung models aim to improve treatment options for airway and lung repair and advance respiratory pathophysiological research. The construction of biomimetic native airways and lungs with tissue-specific biological, mechanical, and configurable features remains challenging.
View Article and Find Full Text PDFHybrid 3D bioprinting for advanced tissue-engineered trachea: merging fused deposition modeling (FDM) and top-down digital light processing (DLP).
Biofabrication
November 2024
Nano-Bio Regenerative Medical Institute, College of Medicine, Hallym University, Chuncheon, 24252, Republic of Korea.
In this present study, we introduce an innovative hybrid 3D bioprinting methodology that integrates fused deposition modeling (FDM) with top-down digital light processing (DLP) for the fabrication of an artificial trachea. Initially, polycaprolactone (PCL) was incorporated using an FDM 3D printer to provide essential mechanical support, replicating the structure of tracheal cartilage. Subsequently, a chondrocyte-laden glycidyl methacrylated silk fibroin hydrogel was introduced via top-down DLP into the PCL scaffold (PCL-Sil scaffold).
View Article and Find Full Text PDFClinical Perspectives and Novel Preclinical Models of Malignant Pleural Mesothelioma: A Critical Review.
ACS Pharmacol Transl Sci
November 2024
Eskisehir Osmangazi University, Faculty of Medicine, Department of Pulmonary Diseases, Lung and Pleural Cancers Research and Clinical Center, Eskisehir 26040, Turkey.
Pleural mesothelioma (PM), a rare malignant tumor explicitly associated with asbestos and erionite exposures, has become a global health problem due to limited treatment options and a poor prognosis, in which the median life expectancy varies depending on the method of treatment. However, the importance of early diagnosis is emphasized, and the practical methods have not matured yet. This study provides a critical overview of PM, addressing various aspects like epidemiology, etiology, diagnosis, treatment options, and the potential use of advanced technologies like microfluidic chip-based models for research and diagnosis.
View Article and Find Full Text PDFIntegration of bioprinting advances and biomechanical strategies forlung modelling.
Biofabrication
November 2024
Department of Mechanical Engineering, University of Saskatchewan, Saskatoon, SK, Canada.
The recent occurrence of the Covid-19 pandemic and frequent wildfires have worsened pulmonary diseases and raised the urgent need for investigating host-pathogen interactions and advancing drug and vaccine therapies. Historically, research and experimental studies have relied on two-dimensional cell culture dishes and/or animal models, which suffer from physiological differences from the human lung. More recently, there has been investigation into the use of lung-on-a-chip models and organoids, while the use of bioprinting technologies has also emerged to fabricate three-dimensional constructs or lung models with enhanced physiological relevance.
View Article and Find Full Text PDFThree-Dimensional-Bioprinted Non-Small Cell Lung Cancer Models in a Mouse Phantom for Radiotherapy Research.
Int J Mol Sci
September 2024
Department of Applied Biochemistry, Institute of Biotechnology, Technische Universität Berlin, 10623 Berlin, Germany.
Lung cancer continues to have one of the highest morbidity and mortality rates of any cancer. Although radiochemotherapy, in combination with immunotherapy, has significantly improved overall survival, new treatment options are urgently needed. However, preclinical radiotherapy testing is often performed in animal models, which has several drawbacks, including species-specific differences and ethical concerns.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!