An acyl lactonization of alkenes with aldehydes under visible-light photoredox catalysis is described. With the protocol, a broad scope of alkenoic acids and aldehydes could be compatible and good functional group tolerance is obtained. A series of acyl lactones are obtained with isolated yields ranging from 50-95%. Mechanistic studies revealed that the transformation should proceed via a radical chain process.
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Quorum sensing signals of the grapevine crown gall bacterium, sp. Rr2-17: use of inducible expression and polymeric resin to sequester acyl-homoserine lactones.
PeerJ
December 2024
The Thomas H. Gosnell School of Life Sciences, Biotechnology and Molecular Bioscience Program, College of Science, Rochester Institute of Technology, Rochester, New York, United States.
Background: A grapevine crown gall tumor strain, sp. strain Rr2-17 was previously reported to accumulate copious amounts of diverse quorum sensing signals during growth. Genome sequencing identified a single luxI homolog in strain Rr2-17, suggesting that it may encode for a AHL synthase with broad substrate range, pending functional validation.
View Article and Find Full Text PDFAcyl-Homoserine Lactone Enhances the Resistance of Anammox Consortia under Heavy Metal Stress: Quorum Sensing Regulatory Mechanism.
Environ Sci Technol
December 2024
Institute of Environmental Engineering, School of Metallurgy and Environment, Central South University, Changsha 410083, China.
Anaerobic ammonium oxidation (anammox) represents an energy-efficient process for the removal of biological nitrogen from ammonium-rich wastewater. However, the susceptibility of anammox bacteria to coexisting heavy metals considerably restricts their use in engineering practices. Here, we report that acyl-homoserine lactone (AHL), a signaling molecule that mediates quorum sensing (QS), significantly enhances the nitrogen removal rate by 24% under Cu stress.
View Article and Find Full Text PDFSalinity stress and recovery of the algal-bacterial granular sludge (ABGS) system under the influence of different N-acyl-homoserine lactones (AHLs).
Bioresour Technol
December 2024
School of Civil Engineering, Wuhan University, Wuhan 430072, China. Electronic address:
The algal-bacterial granular sludge (ABGS) system was established to explore the effect of 1% salinity condition, determine the recovery process following salinity disturbance, and probe the impacts of two N-acyl-homoserine lactones (AHLs) on the system. Exposure to 1% salinity led to the reduction of filaments and an increase in TB-EPS contents within the ABGS system. The phosphorus removal performance of the ABGS system severely decreased at 1% salinity and did not restore fully during the subsequent recovery stage, demonstrating that salinity stress induced long-term inhibition.
View Article and Find Full Text PDFSilent signals: how -acyl homoserine lactones drive oral microbial behaviour and health outcomes.
Front Oral Health
December 2024
Faculty of Dentistry, The University of Hong Kong, Hong Kong, Hong Kong SAR, China.
Background: -acyl homoserine lactones (AHLs) are small signalling molecules predominantly secreted in Gram-negative bacteria.
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Assessment of microbial antagonistic activity and Quorum Sensing Signal Molecule (Cyclopeptides-DKPs and N-Acyl Homoserine Lactones) detection in bacterial strains obtained from avocado thrips (Thysanoptera: Thripidae).
Biotechnol Rep (Amst)
March 2025
Microbiodiversity and bioprospection research group, Laboratorio de Biología Celular 19A-310, Molecular, Facultad de Ciencias, Universidad Nacional de Colombia Sede Medellín, 050034, Colombia.
The control of avocado pests and diseases heavily relies on the use of several types of pesticides, some of which are strictly monitored or not internationally accepted. New sources of bioactive molecules produced by phytopathogen-inhibiting microorganisms offer an excellent alternative for the control of pests and diseases. This study explores the potential antagonistic action against phytopathogenic microorganisms, using bacterial strains obtained from avocado thrips.
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