Osteoarthritis is a common chronic degenerative disease that causes pain and disability with increasing incidence worldwide. The osteochondral junction is a dynamic region of the joint that is associated with the early development and progression of osteoarthritis. Despite the substantial advances achieved in the imaging of cartilage and application to osteoarthritis in recent years, the osteochondral junction has received limited attention. This is primarily related to technical limitations encountered with conventional MR sequences that are relatively insensitive to short T2 tissues and the rapid signal decay that characterizes these tissues. MR sequences with ultrashort echo time (UTE) are of great interest because they can provide images of high resolution and contrast in this region. Here, we briefly review the anatomy and function of cartilage, focusing on the osteochondral junction. We also review basic concepts and recent applications of UTE MR sequences focusing on the osteochondral junction.
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http://dx.doi.org/10.1002/nbm.4843 | DOI Listing |
Radiology
December 2024
From the Department of Radiology, Hanyang University Hospital, 222-1 Wangsimni-ro, Seongdong-gu, Seoul 04763, South Korea (Sunmin Lee, Y.J.K., Seunghun Lee); Department of Radiology, Hanyang University Guri Hospital, Guri, South Korea (J.R.); Department of Radiology, Eunpyeong St Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea (H.Y.L.); Department of Radiology, University of California, Davis, Sacramento, Calif (H.J.); Biostatistics Laboratory, Medical Research Collaborating Center, Industry-University Cooperation Foundation, Hanyang University, Seoul, South Korea (H.W.T., J.K.); and Department of Pre-Medicine, College of Medicine, Hanyang University, Seoul, South Korea (J.K.).
Background The calcified cartilage layer and subchondral bone plate (SBP) contribute to osteoarthritis development. Three-dimensional (3D) ultrashort echo-time (UTE) MRI can help to evaluate calcified cartilage and SBP in various stages of cartilage degradation. Purpose To compare calcified cartilage and SBP abnormalities using 3D UTE MRI with cartilage degradation and osteochondral junction (OCJ) abnormalities observed at proton-density fast spin-echo with fat suppression (PDFS) MRI.
View Article and Find Full Text PDFHistochem Cell Biol
December 2024
School of Mechanical, Medical & Process Engineering, Queensland University of Technology, 60 Musk Ave/Cnr. Blamey St, Kelvin Grove, Brisbane, QLD, 4059, Australia.
Understanding the osteochondral junction, where non-mineralised cartilage and mineralised bone converge, is crucial for joint health. Current sample preparation techniques are insufficient for detailed spatial hyperspectral imaging analysis. Using the enhanced Kawamoto method, we used the super cryo embedding medium's temperature-dependent properties to transfer high-quality tissue samples onto slides for spatial imaging analysis.
View Article and Find Full Text PDFBiomater Adv
February 2025
Department of Orthopaedics, The Second Hospital of Jilin University, Changchun 130041, China. Electronic address:
Despite significant progress in repairing osteochondral injuries using 3D printing technology, most cartilage layer scaffolds are made of degradable materials, making it difficult to simultaneously provide extracellular matrix functionality while replicating the mechanical properties of natural cartilage layers. Additionally, their degradation rate is challenging to align with cartilage regeneration. Furthermore, double-layer scaffolds commonly used for repairing osteochondral often exhibit inadequate bonding between the cartilage layer scaffolds and bone layer scaffolds.
View Article and Find Full Text PDFBMC Oral Health
October 2024
Department of Histology and Embryology, Kanuni Sultan Suleyman Training and Research Hospital, Trabzon, Turkey.
Nat Microbiol
October 2024
Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong Special Administrative Region, China.
Joint pain and osteoarthritis can occur as coronavirus disease 2019 (COVID-19) sequelae after infection. However, little is known about the damage to articular cartilage. Here we illustrate knee joint damage after wild-type, Delta and Omicron variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in vivo.
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