Disruption of quorum sensing pathway of pathogenic microbes is considered as novel approach to fight against infectious diseases. The current study was planned to evaluate the antibiofilm and quorum sensing inhibitory potential of . Antibacterial and antibiofilm potential of extracts was determined through agar well diffusion and crystal violet assay against sinusitis isolates, that is, , while quorum sensing inhibition efficacy of extracts was determined through violacein inhibition assay using as bacterial model The methanolic extract of presented the highest antimicrobial activity against and antibiofilm activity against (77.42 ± 1.51%) while -hexane extract was found to be least active against all tested bacterial strains Quorum sensing inhibition activity of extracts against showed significant dose-dependent inhibition in violacein production by different concentrations of methanolic extract. Furthermore, none of the extracts of showed any hemolytic activity against human RBCs and hold considerable thrombolytic potential in comparison to streptokinase (75.9 ± .46%). In conclusion, findings suggest that leaves are excellent source of phytochemicals with potent antibiofilm and quorum sensing inhibition potential.
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| http://dx.doi.org/10.1177/15593258221132080 | DOI Listing |
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