AI Article Synopsis
- - This study investigated the effects of high-dose (greater than 10 mg/kg) versus low-dose (10 mg/kg or less) tranexamic acid (TXA) on operative time, blood loss, and transfusion needs in craniosynostosis surgery.
- - A systematic review and meta-analysis of 398 patients indicated that administering TXA significantly reduced blood loss and transfusion requirements, but had no effect on operative time.
- - Results showed no significant differences between high and low doses of TXA in terms of the studied outcomes, suggesting that low-dose TXA is effective and carries a low risk of adverse events.
Article Abstract
Unlabelled: This study aimed to compare operative time, blood loss, and transfusion requirement in patients receiving a high tranexamic acid (TXA) dose of greater than 10 mg/kg versus those receiving a low dose of 10 mg/kg or less.
Methods: PubMed, Cochrane Central, and Embase were queried to perform a systematic review with meta-analysis. Studies reporting outcomes of TXA use in craniosynostosis surgery were included. TXA dosing, operative time, blood loss, and transfusion requirement were the primary outcomes studied. Other variables studied included age and types of craniosynostosis.
Results: In total, 398 individuals in the included articles received TXA for craniosynostosis surgery. TXA loading doses ranged from 10 mg/kg to 50 mg/kg. Overall, administration of TXA was not associated with changes in operative time, but was associated with decreased blood loss and transfusion requirement on meta-analysis. Comparison of high dose TXA (>10 mg/kg) versus low dose (10 mg/kg or less) showed no statistical differences in changes in operative time, blood loss, or transfusion requirement.
Conclusions: Overall, TXA reduced blood loss and transfusion requirement in patients undergoing surgery for craniosynostosis. There was no difference in outcomes between high dose and low dose regimens amongst those receiving TXA. Low dose TXA appears adequate to achieve clinical efficacy with a low adverse event rate.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9575957 | PMC |
| http://dx.doi.org/10.1097/GOX.0000000000004526 | DOI Listing |
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