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Current Approaches to Optimize Donor Heart for Transplantation.
J Heart Lung Transplant
December 2024
Department of Cardiothoracic Surgery, NYU Langone Health, New York, NY, USA.
Heart transplantation remains a critical therapy for patients with end-stage heart failure, offering incremental survival and improved quality of life. One of the key components behind the success of heart transplantation is the condition and preservation of the donor heart. In this review, we provide a comprehensive overview of ischemic reperfusion injury, risk factors associated with primary graft dysfunction, current use of various preservation solutions for organ procurement and recent advancements in donor heart procurement technologies.
View Article and Find Full Text PDFA 17-Year Experience of a Large Dedicated Fellowship in Blood and Marrow Transplantation and Cellular Therapy: A Blueprint for Modern Day Training Program.
J Cancer Educ
November 2024
Division of Blood and Marrow Transplantation and Cellular Therapy, Stanford University School of Medicine, Stanford, CA94304, USA.
The field of allogeneic blood and marrow transplantation-cellular therapy (BMT-CT) has evolved through incremental advances. Engineered donor grafts, gene editing and chimeric antigen receptor T-cells are all standard clinical practice. Consequently, the scientific knowledge and complexity of clinical skills needed for next generation of BMT-CT physicians have increased.
View Article and Find Full Text PDFInvestigation of cross-association behavior in water-ethanol solutions: A combined computational-ATR spectroscopy study.
J Chem Phys
November 2024
Department of Chemical and Biochemical Engineering, Technical University of Denmark, Center for Energy Resources Engineering, Building 229, Kongens Lyngby 2800, Denmark.
The water/ethanol system possesses complexities at the molecular level, which render its description a difficult task. For the elucidation of the system's hydrogen bonding features that are the key factors in its complex behavior, we conduct a Density Functional Theory analysis on relevant water/ethanol clusters inside implicit solvent cavities for the determination of the ethanol donor hydrogen bond strength. We record Attenuated Total Reflectance spectra of water/ethanol-OD solutions and utilize our density and refractive index measurements for post-processing.
View Article and Find Full Text PDFCost of COVID-19 vaccine delivery in nine States in Nigeria via the U.S. Government Initiative for Global Vaccine Access.
BMC Health Serv Res
October 2024
Global Immunization Division, Global Health Center, Centers for Disease Control and Prevention, Abuja, Nigeria.
Article Synopsis
- The CDC partnered with African Field Epidemiology Network and Sydani Group in 2022 to aid COVID-19 vaccination efforts in Nigeria and assess the financial costs associated with these vaccination campaigns.
- The study used existing financial data to evaluate costs per dose for vaccination activities in nine states, excluding certain expenses like vaccine purchases and transport.
- The total expenditure for administering 7.46 million doses was approximately US$6.29 million, with the main costs attributed to fieldwork activities (86%) and labor (58%), particularly for vaccination teams and incentives.
Incremental eligibility criteria for the BMT CTN 1507 haploidentical trial for children with sickle cell disease.
Blood Adv
December 2024
Department of Pediatrics, Division of Hematology/Oncology, Vanderbilt-Meharry Sickle Cell Disease Center of Excellence, Vanderbilt University Medical Center, Nashville, TN.
Article Synopsis
- The Blood and Marrow Transplant Clinical Trials Network is running a study to help kids ages 5 to almost 15 with sickle cell disease by using special stem cell transplants.
- They started by only allowing kids who had a clear stroke to join, but then they opened it up to others who had silent brain injuries or high-risk blood flow problems.
- They created different stages for kids to qualify based on serious health issues, like breathing problems or ongoing pain, to ensure the best chance for help in the trial.
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