Multimodal image synthesis has emerged as a viable solution to the modality missing challenge. Most existing approaches employ softmax-based classifiers to provide modal constraints for the generated models. These methods, however, focus on learning to distinguish inter-domain differences while failing to build intra-domain compactness, resulting in inferior synthetic results. To provide sufficient domain-specific constraint, we hereby introduce a novel prototype discriminator for generative adversarial network (PT-GAN) to effectively estimate the missing or noisy modalities. Different from most previous works, we introduce the Radial Basis Function (RBF) network, endowing the discriminator with domain-specific prototypes, to improve the optimization of generative model. Since the prototype learning extracts more discriminative representation of each domain, and emphasizes intra-domain compactness, it reduces the sensitivity of discriminator to pixel changes in generated images. To address this dilemma, we further propose a reconstructive regularization term which connects the discriminator with the generator, thus enhancing its pixel detectability. To this end, the proposed PT-GAN provides not only consistent domain-specific constraints, but also reasonable uncertainty estimation of generated images with the RBF distance. Experimental results show that our method outperforms the state-of-the-art techniques. The source code will be available at: https://github.com/zhiweibi/PT-GAN.
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http://dx.doi.org/10.1109/TIP.2022.3214336 | DOI Listing |
Sensors (Basel)
January 2025
Biomanufacturing Center, Department of Mechanical Engineering, Tsinghua University, Beijing 100084, China.
With the rapid development of sports technology, smart wearable devices play a crucial role in athletic training and health management. Sports fatigue is a key factor affecting athletic performance. Using smart wearable devices to detect the onset of fatigue can optimize training, prevent excessive fatigue and resultant injury, and increase efficiency and safety.
View Article and Find Full Text PDFJ Fluoresc
January 2025
Department of Chemical Sciences, University of Johannesburg, Doornfontein, Johannesburg, South Africa.
Point of Care (POC) diagnosis provides an effective approach for controlling and managing Neglected Tropical Diseases (NTDs). Electrochemical biosensors are well-suited for molecular diagnostics due to their high sensitivity, cost-effectiveness, and ease of integration into POC devices. Schistosomiasis is a prominent NTD highly prevalent in Africa, Asia, and Latin America, with significant socioeconomic implications such as discrimination, reduced work capacity, or mortality, perpetuating the cycle of poverty in affected regions worldwide.
View Article and Find Full Text PDFBioinformatics
January 2025
College of Artificial Intelligence, Nankai University, Tianjin, 300350, China.
Motivation: The drug-disease, gene-disease, and drug-gene relationships, as high-frequency edge types, describe complex biological processes within the biomedical knowledge graph. The structural patterns formed by these three edges are the graph motifs of (disease, drug, gene) triplets. Among them, the triangle is a steady and important motif structure in the network, and other various motifs different from the triangle also indicate rich semantic relationships.
View Article and Find Full Text PDFMolecules
January 2025
Department of Law, University of Bergamo, Via Moroni 255, 24127 Bergamo, Italy.
Background: The detection of explosives in crime scene investigations is critical for forensic science. This study explores the application of laser desorption (LD) ion mobility spectrometry (IMS) as a novel method for this purpose utilising a new IMS prototype developed by MaSaTECH.
Methods: The LD sampling technique employs a laser diode module to vaporise explosive traces on surfaces, allowing immediate analysis by IMS without sample preparation.
Neurocrit Care
January 2025
Department of Health Research, Medical Technology, SINTEF, Trondheim, Norway.
Background: Optic nerve sheath diameter (ONSD) is a promising noninvasive parameter for intracranial pressure (ICP) assessment. However, in the setting of aneurysmal subarachnoid hemorrhage (aSAH), several previous studies have reported no association between ultrasonically measured ONSD and ICP. In this study, we evaluate ONSD in patients with aSAH using a novel method of automated real-time ultrasonographic measurements and explore whether factors such as having undergone surgery affects its association to ICP.
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