Unusual cascade transformation involving ring opening and 1,2-alkyl shift was observed upon the reduction of 4'-spiro[indole-3,5'-isoxazoles] or 2-(3-oxoindolin-2-yl)acetonitriles with sodium borohydride. This reaction allowed for expeditious and highly efficient preparation of 2-(1-Indol-3-yl)acetamides with antiproliferative properties.

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http://dx.doi.org/10.1021/acs.joc.2c01627DOI Listing

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