Doxycycline is a broad-spectrum bacteriostatic antibiotic that belongs to the tetracycline class. It is a relatively safe medication with reported side effects being gastrointestinal symptoms, bone and teeth discoloration, photosensitivity, and renal toxicity. Acute pancreatitis (AP) is an uncommon adverse effect with only a few reported cases in the literature. Despite tetracyclines being labeled as a probable causative agent of drug-induced pancreatitis (DIP), doxycycline has been rarely implicated. Herein we present the case of a 65-year-old patient who developed recurrent doxycycline-induced pancreatitis after she was inadvertently started on the medication for community-acquired pneumonia. The most common causes of pancreatitis were ruled out during her hospital admission and she was subsequently diagnosed with DIP. She was successfully treated with the cessation of the offending agent and with supportive therapy. It is critical that clinicians are aware of the possible association between doxycycline and pancreatitis to further aid in the prompt diagnosis and treatment of this condition.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9568648 | PMC |
| http://dx.doi.org/10.7759/cureus.29171 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Blame it on the Drug: A Rare Case of Recurrent Doxycycline-Induced Pancreatitis.
Cureus
September 2022
Internal Medicine, University of Central Florida College of Medicine, Graduate Medical Education/North Florida Regional Medical Center, Gainesville, USA.
Doxycycline is a broad-spectrum bacteriostatic antibiotic that belongs to the tetracycline class. It is a relatively safe medication with reported side effects being gastrointestinal symptoms, bone and teeth discoloration, photosensitivity, and renal toxicity. Acute pancreatitis (AP) is an uncommon adverse effect with only a few reported cases in the literature.
View Article and Find Full Text PDFIn vivo metabolic imaging identifies lipid vulnerability in a preclinical model of Her2+/Neu breast cancer residual disease and recurrence.
NPJ Breast Cancer
September 2022
Department of Biomedical Engineering, Duke University, Durham, NC, USA.
Article Synopsis
- Recurrent cancer cells are a major cause of death in breast cancer, especially in patients with high Her2 expression.
- This study investigates the metabolic changes in breast tumors as they transition through regression, dormancy, and recurrence, using imaging techniques to track energy production shifts.
- Fast-recurrence tumors change their energy source from glucose to fatty acids, and treatment with a fatty acid inhibitor can enhance glucose uptake and prolong survival, highlighting the importance of timing for effective therapy.
Nuclear envelope protein lamin B receptor protects the genome from chromosomal instability and tumorigenesis.
Hum Mol Genet
February 2023
Chromosome Biology Lab (CBL), Indian Institute of Science Education and Research (IISER), Pune 411008, India.
Lamin B Receptor (LBR) is an inner nuclear membrane protein that assembles the nuclear envelope post mitosis. Here we show that LBR depletion induces mitotic defects accompanied by recurrent chromosomal losses. In addition, LBR knockdown results in nuclear aberrations such as nuclear blebs and micronuclei, with chromosomes showing higher frequency of losses, being enriched within the micronucleus.
View Article and Find Full Text PDFThe CRTC1-MAML2 fusion is the major oncogenic driver in mucoepidermoid carcinoma.
JCI Insight
April 2021
Department of Molecular Genetics and Microbiology.
No effective systemic treatment is available for patients with unresectable, recurrent, or metastatic mucoepidermoid carcinoma (MEC), the most common salivary gland malignancy. MEC is frequently associated with a t(11;19)(q14-21;p12-13) translocation that creates a CRTC1-MAML2 fusion gene. The CRTC1-MAML2 fusion exhibited transforming activity in vitro; however, whether it serves as an oncogenic driver for MEC establishment and maintenance in vivo remains unknown.
View Article and Find Full Text PDFInfertility and recurrent miscarriage with complex II deficiency-dependent mitochondrial oxidative stress in animal models.
Mech Ageing Dev
April 2016
Department of Molecular Life Science, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan.
Oxidative stress is associated with some forms of both male and female infertility. However, there is insufficient knowledge of the influence of oxidative stress on the maintenance of a viable pregnancy, including pregnancy complications and fetal development. There are a number of animal models for understanding age-dependent decrease of reproductive ability and diabetic embryopathy, especially abnormal spermatogenesis, oogenesis and embryogenesis with mitochondrial dysfunctions.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!