Background: Aerosol-generating procedures (AGPs), such as nasoendoscopy, are considered high-risk during the COVID-19 pandemic due to risk of virus aerosol transmission. We aim to evaluate the efficacy of an innovative system in reduction of aerosol contamination.
Methods: Pilot study involving 15 healthy volunteers performing aerosol-generating activities with the prototype, compared with and without a standard surgical mask.
Results: We found an increased frequency of smaller-sized particle emissions for all four expiratory activities. The particle emission rate with the prototype mask was significantly slower over time for the smallest sized particle (0.3 μm) during breathing, speaking and singing compared with similar activities without the mask (p < .05). We found similar trends for coughing for larger particles but that did not reach statistical significance.
Conclusion: The innovation offers good protection against aerosol transmission through the physical barrier of the mask, the negative pressure environment within the mask, and the unit's dual filtration function.
Level Of Evidence: Level 2b.
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http://dx.doi.org/10.1002/lio2.913 | DOI Listing |
Animal Model Exp Med
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Department of Pharmacy, Faculty of Health and Life Sciences, Daffodil International University, Dhaka, Bangladesh.
Polyphenols, a diverse group of naturally occurring compounds found in plants, have garnered significant attention for their potential therapeutic properties in treating neurodegenerative diseases (NDs). The Wnt/β-catenin (WβC) signaling pathway, a crucial player in neurogenesis, neuronal survival, and synaptic plasticity, is involved in several cellular mechanisms related to NDs. Dysregulation of this pathway is a hallmark in the development of various NDs.
View Article and Find Full Text PDFACS Nano
January 2025
State Key Laboratory of Integrated Chips and Systems, Frontier Institute of Chip and System, School of Microelectronics, Fudan University, Shanghai 200433, China.
The exponential growth of the Internet of Things (IoTs) has led to the widespread deployment of millions of sensors, crucial for the sensing layer's perception capabilities. In particular, there is a strong interest in intelligent photonic sensing. However, the current photonic sensing device and chip typically offer limited functionality, and the devices providing their power take up excessive amounts of space.
View Article and Find Full Text PDFACS Appl Mater Interfaces
January 2025
Shenzhen Key Laboratory of Intelligent Robotics and Flexible Manufacturing Systems, Department of Mechanical and Energy Engineering, Southern University of Science and Technology, Shenzhen 518055, China.
This study presents the development of a solar-driven thermally regenerative electrochemical cell (STREC) for continuous power generation. Key innovations include dual-function carbon-based electrodes for efficient solar absorption and electrochemical reactions, a transparent and ultrainsulating silica aerogel to maximize solar spectrum transmission while minimizing heat loss, and a compact heat exchanger to recover heat from hot cell streams. Under 1 sun conditions, the STREC achieves a power density of 912.
View Article and Find Full Text PDFColloids Surf B Biointerfaces
January 2025
College of Chemistry, Fuzhou University, Fuzhou, Fujian 350116, China; The National & Local Joint Engineering Research Center on Biopharmaceutical and Photodynamic Therapy Technologies, Fuzhou University, Fuzhou, Fujian 350116, China. Electronic address:
Angiogenesis provides essential nutrients and oxygen to tumors during tumorigenesis, facilitating invasion and metastasis. Consequently, inhibiting tumor angiogenesis is an established strategy in anti-cancer therapy. In this study, we engineered a dual-function nanosystem with both antiangiogenic and photodynamic properties.
View Article and Find Full Text PDFInt J Mol Sci
December 2024
Molecular Genetics, The Weizmann Institute of Science, Rehovot 7610001, Israel.
Interleukin-18 (IL-18) serves a dual function in the immune system, acting as a "double-edged sword" cytokine. Depending on the microenvironment and timing, IL-18 can either drive harmful inflammation or restore immune homeostasis. Pathologies characterized by elevated IL-18, recently proposed to be termed IL-18opathies, highlight the therapeutic potential for IL-18 blockade.
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