Hydrogen peroxide (HO) is a type of reactive oxygen species that regulates essential biological processes. Despite the central role of HO in pathophysiological states, available molecular probes for assessing HO are still limited. This work develops hyperpolarized N-boronobenzyl-4-cyanopyridinium (N-BBCP) as a rationally designed molecular probe for detecting HO. The N-BBCP demonstrated favorable physicochemical and biochemical properties for HO detection and dynamic nuclear polarization, allowing noninvasive detection of HO. In particular, N-BBCP and the products possessed long spin-lattice relaxation times and spectrally resolvable N chemical shift differences. The performance of hyperpolarized N-BBCP was demonstrated both and with time-resolved N-MRS. This study highlights a promising approach to designing a reaction-based N-labeled molecular imaging agent for detecting oxidative stress
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9908030 | PMC |
| http://dx.doi.org/10.1021/acssensors.2c01720 | DOI Listing |
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