The alkaloid composition of was studied, in which the pyrrolizidine alkaloids echinatine and trachelanthamine N-oxide, as well as two new quaternary salts namely rinderidine and the oblongifolidine were isolated. The structures of the isolated new alkaloids were elucidated by NMR spectroscopy. The absolute configuration of lindelofine, trachelanthamine N-oxide, rinderidine and oblongifolidine was established by single crystal X-ray diffraction as: 1 , 4 , 8 , 2', 3'; 1 , 4, 8, 2', 3'; 4 , 7, 8 , 2', 3'; 4 , 7, 8 , 2', 3' (7'', 8'') respectively. Both new pyrrolizidine alkaloids showed no cytotoxicity against four cancer cell lines such as HeLa, НEр-2, HBL-100 and CCRF-CEM.
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| http://dx.doi.org/10.1080/14786419.2022.2134865 | DOI Listing |
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Rinderidine and oblongifolidine new pyrrolizidine alkaloids from M. Popov and their absolute configurations.
Nat Prod Res
April 2024
Department of Physical Methods of Research, Acad. S.Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, Tashkent, Uzbekistan.
The alkaloid composition of was studied, in which the pyrrolizidine alkaloids echinatine and trachelanthamine N-oxide, as well as two new quaternary salts namely rinderidine and the oblongifolidine were isolated. The structures of the isolated new alkaloids were elucidated by NMR spectroscopy. The absolute configuration of lindelofine, trachelanthamine N-oxide, rinderidine and oblongifolidine was established by single crystal X-ray diffraction as: 1 , 4 , 8 , 2', 3'; 1 , 4, 8, 2', 3'; 4 , 7, 8 , 2', 3'; 4 , 7, 8 , 2', 3' (7'', 8'') respectively.
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