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Can oxymetazoline simulate the outcomes of septoplasty and inferior turbinate reduction surgery?
Int Forum Allergy Rhinol
May 2023
Department of Otolaryngology - Head & Neck Surgery, The Ohio State University, Columbus, Ohio, USA.
Rhinomanometry Versus Computational Fluid Dynamics: Correlated, but Different Techniques.
Am J Rhinol Allergy
March 2021
Department of Biomedical Engineering, Marquette University and The Medical College of Wisconsin, Milwaukee, Wisconsin.
Background: Past studies reported a low correlation between rhinomanometry and computational fluid dynamics (CFD), but the source of the discrepancy was unclear. Low correlation or lack of correlation has also been reported between subjective and objective measures of nasal patency.
Objective: This study investigates (1) the correlation and agreement between nasal resistance derived from CFD (R) and rhinomanometry (R), and (2) the correlation between objective and subjective measures of nasal patency.
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PLoS One
April 2019
Department of Biomedical Engineering, Marquette University & The Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America.
Computational fluid dynamics (CFD) allows quantitative assessment of transport phenomena in the human nasal cavity, including heat exchange, moisture transport, odorant uptake in the olfactory cleft, and regional delivery of pharmaceutical aerosols. The first step when applying CFD to investigate nasal airflow is to create a 3-dimensional reconstruction of the nasal anatomy from computed tomography (CT) scans or magnetic resonance images (MRI). However, a method to identify the exact location of the air-tissue boundary from CT scans or MRI is currently lacking.
View Article and Find Full Text PDFComputational fluid dynamics (CFD) was used to simulate air flow changes in reconstructed nasal passages based on magnetic resonance imaging (MRI) data from a previous clinical study of 0.05% Oxymetazoline (Vicks Sinex Micromist®). Total-pressure boundary conditions were uniquely applied to accommodate low patency subjects.
View Article and Find Full Text PDFThe investigation of the interaction between Oxymetazoline hydrochloride and mucin by spectroscopic approaches.
Spectrochim Acta A Mol Biomol Spectrosc
February 2013
Key Laboratory of Theoretical Chemistry and Molecular Simulation of Ministry of Education, Hunan Province College Key Laboratory of QSAR/QSPR, School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan 411201, China.
The fluorescence and ultraviolet spectroscopy were explored to study the interaction between Oxymetazoline hydrochloride (OMZH) and mucin under imitated physiological condition. The results demonstrated that the fluorescence quenching mechanism between OMZH and mucin is a combined quenching process. The binding constants (K(a)), binding sites (n) and the corresponding thermodynamic parameters (ΔG, ΔH, and ΔS) of the interaction system were calculated at different temperatures.
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