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Challenges and opportunities in stewardship among solid organ transplant recipients with Candida auris bloodstream infections. | LitMetric

Challenges and opportunities in stewardship among solid organ transplant recipients with Candida auris bloodstream infections.

Transpl Infect Dis

Department of Infection Prevention and Control, Jackson Health System, Miami, Florida, USA.

Published: October 2022

AI Article Synopsis

  • Candida auris is a rising threat for bloodstream infections among solid organ transplant recipients, with a study identifying five such cases during 2020-2021.
  • The majority of patients received micafungin therapy; however, there were notable concerns, including a 20% mortality rate and challenges in clearing the infection.
  • To improve outcomes, hospitals should focus on rapid diagnosis and treatment, better antifungal strategies, and prevention efforts to protect the gut microbiome of transplant patients.

Article Abstract

Background: Candida auris is an emerging nosocomial pathogen worldwide. However, there has been little published on the management of C. auris in solid organ transplant recipients.

Methods: A single-center, retrospective cohort study was conducted to evaluate C. auris bloodstream infections in solid organ transplant recipients between January 2020 and December 2021. Patient-related and outcomes data were extracted from electronic medical records.

Results: Of the 42 patients identified with C. auris bloodstream infections, five were in solid organ transplant recipients (1 heart, 3 liver, and 1 combined liver-kidney). The median time to fungemia from hospital admission was 43 days, and the median time to fungemia from transplant was 18 days. All patients received micafungin as initial treatment, at a median of 6 hours from pathogen detection. Four patients achieved blood clearance, two patients had persistent fungemia, and two patients developed secondary complications from hematogenous spread. One patient died, resulting in a mortality rate of 20%.

Conclusions: Solid organ transplant recipients are at high risk for developing C. auris bloodstream infections. In order to prevent graft loss and mortality, best practices for the management of C.auris should include rapid screening, diagnosis, and treatment. While echinocandins are considered first-line, antifungal selection should be based on susceptibilities and site of infection. Data to support routine use of combination therapy are lacking, however there may be a role for refractory cases. Prevention efforts against C. auris infection are especially important given the lack of effective decolonization strategies. For transplant recipients, hospitals should seek opportunities to restore patients' gut microbiome by curtailing unnecessary hospital procedures and inappropriate antimicrobial use. Further research and national guidelines are needed to better direct stewardship in this field.

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Source
http://dx.doi.org/10.1111/tid.13919DOI Listing

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