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| http://dx.doi.org/10.1503/cmaj.220680 | DOI Listing |
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Chronic Diarrhea Owing to Microscopic Colitis: A Cohort Study with Insights into Diagnostic Challenges and Size of the Problem.
Diagnostics (Basel)
October 2024
Internal Medicine Department, Faculty of Medicine, Zagazig University, Zagazig 44519, Egypt.
Article Synopsis
- Microscopic colitis (MC) is a significant but often overlooked cause of chronic diarrhea, especially when colonoscopy results appear normal, prompting the need for more thorough diagnostic methods.
- A study involving 116 patients showed that 32.8% were diagnosed with MC, with lymphocytic colitis being more prevalent, and elevated inflammatory markers like fecal calprotectin, ESR, and CRP were linked to MC.
- Symptoms such as nocturnal diarrhea and abdominal pain were strongly associated with MC, and specific cutoff values for inflammatory markers demonstrated high accuracy for diagnosis, indicating the necessity for further exploration and validation in future research.
PROTON-PUMP INHIBITORS ARE ASSOCIATED WITH AN INCREASED RISK OF MICROSCOPIC COLITIS: A POPULATION-BASED STUDY AND REVIEW OF THE LITERATURE.
Arq Gastroenterol
October 2024
Department of Gastroenterology, Firelands Health, Sandusky, OH, USA.
Background: Microscopic colitis is a relatively new diagnosis that was first described in the 1980s. Patients usually present with chronic watery and non-bloody diarrhea and are typically characterized by an unremarkable gross appearance of the colon on lower endoscopy while having evidence of lymphocytic infiltration of the lamina propria and the epithelium on histology. Two subtypes have been described in the literature: Collagenous colitis, with marked thickening of the subepithelial layer, and Lymphocytic colitis.
View Article and Find Full Text PDFMicroscopic Colitis: An Underestimated Disease of Growing Importance.
J Clin Med
September 2024
Department of Digestive Tract Disease, Medical University of Lodz, 90-647 Lodz, Poland.
Article Synopsis
- The paper aims to increase awareness of microscopic colitis (MC), a chronic inflammatory bowel disease, focusing on its recognition, risk factors, diagnosis, management, and complications.
- MC is characterized by nonspecific symptoms like watery diarrhea, which makes diagnosis challenging, and the average onset age is around 62-65 years, with women being more affected.
- Risk factors for MC include lifestyle factors like smoking and alcohol consumption, various medications, and other health conditions; treatment typically involves budesonide or other therapies tailored to individual cases.
Rapid identification of primary atopic disorders (PAD) by a clinical landmark-guided, upfront use of genomic sequencing.
Allergol Select
October 2024
Center for Child and Adolescent Health, Helios Hospital Krefeld, Academic Hospital of RWTH Aachen, Krefeld.
Article Synopsis
- Primary atopic disorders (PAD) are rare genetic conditions caused by specific gene variants that affect skin and immune function, making diagnosis challenging among common allergic disease cases.
- Identifying PAD requires recognizing clinical red flags like family history and unusual infections, as conventional lab tests are inadequate for definitive diagnosis.
- Whole-genome sequencing (WGS) enhances diagnostic efficiency and accuracy, but requires careful interpretation and collaboration among specialists to effectively manage PAD cases.
[Lymphocytic colitis associated with duloxetine].
Rev Esp Geriatr Gerontol
October 2024
F.E.A. Servicio de Geriatría, Hospital Universitario Central de la Cruz Roja, San José y Santa Adela, Madrid, España; Universidad Alfonso X El Sabio, Madrid, España.
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