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Identification of Tumor-Suppressive Controlled Genes: as a Therapeutic Target in Breast Cancer.
Noncoding RNA
November 2024
Department of Functional Genomics, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan.
Our recently created RNA-sequence-based microRNA (miRNA) expression signature in breast cancer clinical specimens revealed that some family members were significantly downregulated in cancer tissues. Based on TCGA database analyses, we observed that among the family members, (the passenger strand derived from pre-) was significantly downregulated in breast cancer (BC) clinical specimens, and its low expression predicted worse prognoses. Ectopic expression assays showed that transfected cancer cells (MDA-MB-157 and MDA-MB-231) had their aggressive phenotypes significantly suppressed, e.
View Article and Find Full Text PDFNuclear Receptor Subfamily 4 Group A Member 3: A Potential Marker of Endometriosis.
Discov Med
December 2024
Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, 610017 Chengdu, Sichuan, China.
Background: Nuclear receptor subfamily 4 group A member 3 () is lowly expressed in ectopic endometrium and can be degraded by ubiquitination in vascular endothelial cells. Murine double minute 2 () is predicted to be the ubiquitin ligase of . Hence, we investigated the effects of and on endometriosis and clarified corresponding regulatory mechanisms.
View Article and Find Full Text PDFUltrasound measurements and normal findings in the thyroid gland.
Med Ultrason
December 2024
Department General Internal Medicine (DAIM), Hospitals Hirslanden Bern Beau Site, Salem and Permanence, Bern.
The present work describes the process of the sonographic examination, normal findings and measurements in the B-mode ultrasound evaluation. Reference is made to anatomical variants in shape, the pyramidal lobe, tubercle of Zuckerkandl, ectopic thyroid tissue, and their significance. Particular attention is paid to the reference values, the very miscellaneous reference values in different geographic regions of the world and influencing factors.
View Article and Find Full Text PDFIntroduction: Thyroid and salivary gland cytopathology frequently present diagnostic challenges due to complex presentations, overlapping features between benign and malignant conditions, particularly with grey-zone entities and rare pathologies. To address these issues, the 45th European Congress of Cytology (ECC) held a slide seminar focused on challenging cases. This article reviews key findings from the six cases discussed, emphasizing the importance of a comprehensive diagnostic approach.
View Article and Find Full Text PDFDiagnostic Value of Nuclear Hybrid Imaging in Malignant Struma Ovarii: A Systematic Review of Case Reports.
Diagnostics (Basel)
November 2024
Faculty of Medicine, Department of Medical Imaging and Nuclear Medicine, "Iuliu Hațieganu" University of Medicine and Pharmacy, 8 V. Babeș St., 400006 Cluj-Napoca, Romania.
Background: Struma ovarii is a rare tumor, a type of ovarian mature teratoma consisting over 50% of its mass in thyroid ectopic tissue; 5% to 10% of cases, as described in the literature, are malignant and well known as malignant struma ovarii or thyroid cancer from struma ovarii. Due to the limited number of malignant struma ovarii cases, the diagnostic and therapeutic approach of malignant struma ovarii lacks in standardization.
Methods: We performed a comprehensive search on the English language PubMed and Google Scholar.
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