Background And Objectives: The aim of this study was to investigate the prevalence of posttraumatic stress disorder (PTSD) and clinical correlates in Chinese methamphetamine patients.
Methods: We analyzed 481 Chinese methamphetamine patients.
Results: The prevalence of PTSD among Chinese methamphetamine patients was 7.90% (38/481), which was higher than in western countries. Binary logistic regression showed that age, smoking, abstinence time, age of onset, and DDQ control dimensions were associated with PTSD.
Conclusions And Scientific Significance: Our results indicated that some demographic and clinical variables were associated with PTSD in Chinese methamphetamine patients, which provided evidence for PTSD comorbidity with methamphetamine.
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http://dx.doi.org/10.1111/ajad.13348 | DOI Listing |
Addict Behav
January 2025
CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China.
Eur J Med Chem
January 2025
Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022, China; School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, Anhui, 230026, China. Electronic address:
Substance use disorders (SUDs) present a critical global health challenge, as current treatment options often prove insufficient, particularly for substances like ketamine and methamphetamine. In this study, we developed a novel immunotherapeutic strategy utilizing protein-free, polymer-based vaccines, with hyperbranched polyethylenimine (Hb-PEI) as a carrier to enhance immune specificity and remove the production of non-specific antibodies. Haptens for ketamine and methamphetamine were covalently conjugated to the Hb-PEI carrier, along with the Toll-like receptor (TLR) 7/8 agonist 1V209, to stimulate targeted humoral immune responses.
View Article and Find Full Text PDFSex Transm Infect
January 2025
Stanley Ho Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Hong Kong, Hong Kong, China
Background: Chemsex engagement is known to be associated with higher-risk sexual behaviour, HIV and sexually transmitted infection (STI). To reduce HIV infection risk, pre-exposure prophylaxis (PrEP) is increasingly used in the men who have sex with men (MSM) community. This study aims to examine the interrelationship between chemsex engagement and PrEP use in MSM.
View Article and Find Full Text PDFFuture Med Chem
January 2025
Centre for Drug and Herbal Development, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
Methamphetamine (METH) is a highly addictive illicit psychostimulant with a significant annual fatality rate. Emerging studies highlight its role in neuroinflammation and a range of neurological disorders. This review examines the current landscape of potential drug targets for managing neuroinflammation in METH use disorders (MUDs), with a particular focus on the rationale behind targeting Toll-like receptor 4 (TLR4), the NLR family pyrin domain containing 3 (NLRP3) inflammasome, and other promising targets.
View Article and Find Full Text PDFMol Neurobiol
December 2024
NHC Key Laboratory of Drug Addiction Medicine, School of Forensic Medicine, Kunming Medical University, 1168 West Chunrong Road, Yuhua Avenue Chenggong District, Kunming, 650500, China.
Co-exposure to methamphetamine (METH) abuse and HIV infection exacerbates central nervous system damage. However, the underlying mechanisms of this process remain poorly understood. This study aims to explore the roles of neuronal autophagy in the synergistic damage to the central nervous system caused by METH and HIV proteins.
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