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| http://dx.doi.org/10.34067/KID.0008112021 | DOI Listing |
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Is an oritavancin catheter lock solution active against biofilms of staphylococci and enterococci?
Heliyon
January 2025
Department of Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Background: Oritavancin (ORT) is a new single-dose lipoglycopeptide showing activity against staphylococci and vancomycin-resistant enterococci. However, there is no data regarding its potential use as a catheter lock solution are scarce. We constructed an model to analyze the efficacy and stability of an ORT lock solution against the biofilm of staphylococci and enterococci over 7 days at 37 °C.
View Article and Find Full Text PDFVancomycin Dosing in Patients on Intermittent Hemodialysis-A Retrospective Study.
Clin Ther
January 2025
Pharmacy Department, Alice Springs Hospital, Alice Springs, Australia; Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Alice Springs, NT, Australia.
Purpose: To determine the incidence of therapeutic target attainment using a three-times per week protocol for vancomycin therapy given during the last hour of intermittent hemodialysis (HD).
Methods: A single-center retrospective cohort study was conducted of patient medical records in a remote dialysis center from January 2017 to July 2023. Adult patients with chronic kidney disease stage 5 on ≥3 months of intermittent HD who had received a course of vancomycin therapy with ≥1 serum vancomycin concentration recorded were included.
Ultrasound-triggered release of vancomycin from a novel spinal device: Antibiotic release and efficacy in vivo.
Int J Pharm
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Department of Radiology, Thomas Jefferson University, 132 S. 10(th) Street, Main 10(th) Floor, Philadelphia, PA 19107, USA.
Post-surgical spinal infection occurs in up to 20% of patients, despite aggressive peri-operative antibiotic treatments. To improve prophylaxis, we have designed and evaluated an ultrasound-activated prophylactic antibiotic release system to combat post-surgical bacterial survival. Polylactic acid (PLA) clips (1 cm) were 3D-printed with an interior reservoir (0.
View Article and Find Full Text PDFA Rare Presentation of Bacteremia Secondary to Skin and Soft Tissue Infection.
J Community Hosp Intern Med Perspect
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University Maryland Medical Center Midtown Campus, Department of Internal Medicine, USA.
is a rod-shaped, flagellated, non-lactose fermenting, gram negative bacterium, usually found in water and soil habitats. generally causes nosocomial infections in immunocompromised patients. Increased infection rates are seen in those patients with medical devices inserted, due to this organism's innate ability to attach to moist and inanimate objects.
View Article and Find Full Text PDFPoor Outcome of Rare Lactobacillus Bacteremia and Endocarditis in a Patient With Frequent Consumption of Live Culture Yogurts.
J Community Hosp Intern Med Perspect
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Division of Infectious Disease, Department of Internal Medicine, Naples Comprehensive Health, Naples, FL, USA.
is a gram-positive bacterium commonly found in dairy products and used as a probiotic due to its resistance to acid and bile. While generally considered safe, rare cases of bacteremia and endocarditis have been reported, primarily in individuals with significant risk factors. This report discusses an elderly male with a history of cardiovascular diseases, diabetes, and asthma, who developed bacteremia and endocarditis after consuming large quantities of Greek yogurt.
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