Rhupus syndrome, a rare coexistence of systemic lupus erythematosus (SLE) and rheumatoid arthritis, is characterized by symmetrical erosive polyarthritis and permanent deformities in addition to the clinical and serological characteristics of SLE. Its prognosis is further complicated by neurological and hematological involvement, which dramatically lowers patients' perceptions of their quality of life in terms of their health. Rhupus individuals have significantly less kidney involvement than SLE patients do. We present a case of a young female who had symmetric, bilateral, erosive polyarthritis for one and a half years preceding the signs and symptoms of SLE, which occurred about six months later.
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| http://dx.doi.org/10.7759/cureus.29018 | DOI Listing |
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Faculty of Medicine, Division of Pediatric Rheumatology, Department of Pediatrics, Hacettepe University, Ankara, Turkey.
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View Article and Find Full Text PDFRhupus syndrome: Description of 9 cases with special attention to the HLA-DR genotype.
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Article Synopsis
- - Rhupus is a rare syndrome that combines symptoms of rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), characterized by specific autoantibodies and erosive polyarthritis.
- - This study analyzed the HLA-DR genetic profiles of 9 patients diagnosed with rhupus, finding that it commonly occurs in women with early RA symptoms and noteworthy serological markers like ANA, RF, and anti-CCP.
- - Results indicated a higher prevalence of certain HLA-DR types (HLA-DR1 and DR9) in rhupus patients compared to those with RA or SLE, suggesting potential for early identification of rhupus before an overlap diagnosis is made. *
Article Synopsis
- Rhupus syndrome is a rare condition combining features of rheumatoid arthritis and lupus, with few treatment options and reports on its severe forms.
- Treatment with belimumab has shown promise, as evidenced by a case where the patient’s anti-CCP and anti-dsDNA antibody levels significantly decreased following treatment.
- Measuring these antibody levels can be useful for diagnosing and monitoring treatment effectiveness in patients with Rhupus syndrome.
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