Herein, we report a synthetic protocol for the synthesis of carbamates by employing zinc chloride as a catalyst from carbamoyl chlorides and aromatic/aliphatic alcohols. The developed protocol successfully utilizes the gram-scale synthesis of the FDA-approved rivastigmine drug and its derivative. The utility of zinc chloride over other catalysts such as zinc dust and zinc acetate exhibits a 49-87% yield of carbamates.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9557893 | PMC |
| http://dx.doi.org/10.1021/acsomega.2c05350 | DOI Listing |
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