AI Article Synopsis
- - A study with 120 volunteers tested the effects of probiotic yogurt (containing UA-degrading strain GR-3) versus conventional yogurt on reducing uric acid levels over 2 months.
- - Probiotic yogurt significantly lowered serum uric acid levels by 26.2% compared to just 8.6% for conventional yogurt, and it increased uric acid excretion in urine and feces.
- - Additional analyses indicated that the probiotics may contribute to reduced inflammation, suggesting they could be a useful and cost-effective treatment for hyperuricemia.
Article Abstract
Probiotics have demonstrated the potential to ameliorate hyperuricemia in animals, but their effectiveness and mechanism of action in humans has been understudied. A randomized, double-blinded, controlled research was conducted with 120 volunteers, who consume either a probiotic yogurt containing a UA-degrading strain GR-3 or a conventional yogurt for 2 months, to investigate probiotic yogurt helped decrease uric acid levels in the at-risk human population. Serum UA levels showed that the probiotic yogurt caused a significant decrease than the consumption of conventional yogurt (26.2% ± 2.3% vs. 8.6% ± 1.1%), and contributed to the UA excretion in the feces and urine (7.4% ± 2.1% and 13.8% ± 3.4%, respectively, 1.9% ± 1.1% and 5.1% ± 2.2%, respectively). Metabolomics and microbial community analysis showed a positive correlation with enhanced anti-inflammation of the host. Our findings suggest an effective and economical therapeutic adjuvant in treating hyperuricemia.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9556918 | PMC |
| http://dx.doi.org/10.1016/j.isci.2022.105198 | DOI Listing |
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