A functional vasculature for survival remains a challenge for tissue regeneration, which is indispensable for oxygen and nutrient supply. Utilizing mesenchymal stromal cells (MSCs) to alleviate tissue ischemia and repair dysfunctional or damaged endothelium is a promising strategy. Compared to other populations of MSCs, adipose-derived stromal cells (ASCs) possess a more significant proangiogenic potential and are abundantly available. Cell sheet technology has recently been widely utilized in bone engineering. Compared to conventional methods of seeding seed cell suspension onto biological scaffolds, cell sheet technology prevents cell loss and preserves the extracellular matrix (ECM). Nevertheless, the proangiogenic potential of ASC sheets remains unknown. In this study, rat ASC sheets were constructed, and their macro- and microstructures were examined. In addition, we investigated the effects of ASCs and ASC sheets on the biological properties and angiogenic capacity of endothelial cells (ECs). The results demonstrated that the ASC sheets gradually thickened as the number of cells and ECM increased over time and that the cells were in an active state of secretion. Similar to ASC-CM, the conditioned medium (CM) of ASC sheets could significantly enhance the proliferative capacity of ECs. ASC sheet-CM has significant advantages over ASC-CM in promoting the migration and angiogenesis of ECs, where the exosomes secreted by ASC sheets play an essential role. Therefore, using ASC sheets for therapeutic tissue and organ regeneration angiogenesis may be a valuable strategy.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9556194 | PMC |
| http://dx.doi.org/10.1155/2022/2601764 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Harmonizing Wide Voltage Window and High Energy Density toward Asymmetric All-Solid-State Supercapacitor.
Small
December 2024
School of Materials Science and Chemical Engineering, Xi'an Technological University, Xi'an, 710032, P. R. China.
All-solid-state supercapacitors are known for their safety, stability, and excellent cycling performance. However, their limited voltage window results in lower energy density, restricting their widespread application in practical scenarios. Therefore, in this work, CC/MoO@TiCT negative electrode and MoAl-MnO/CC positive electrode materials are synthesized and prepared by electrochemical deposition co-coating and one-step hydrothermal methods, respectively, and assembled into an asymmetric supercapacitor (ASC) device based on the two electrode materials.
View Article and Find Full Text PDFExtracellular vesicles from human adipose-derived stem cell spheroids: Characterization and therapeutic implications in diabetic wound healing.
Mater Today Bio
December 2024
Department of Surgery, National Taiwan University Hospital and College of Medicine, Taipei 100, Taiwan.
Article Synopsis
- The management of diabetic wounds is difficult, but extracellular vesicles (EVs) from human adipose-derived stem cells (hASCs) show potential for treatment despite challenges with their quantity and quality.
- A novel method using cell spheroids to culture hASCs successfully increased the yield and angiogenic properties of the EVs, leading to improved wound healing characteristics.
- In vivo tests on diabetic rats demonstrated that these enhanced EVs significantly improved collagen production, wound closure, and blood vessel formation, suggesting a promising new approach for treating diabetic wounds.
Thiol-functionalized conductive Co-MOF and its derivatives S-doped Co(OH) nanoflowers for high-performance supercapacitors.
J Colloid Interface Sci
February 2025
School of Chemistry and Chemical Engineering, Guangxi Minzu University, Nanning 530006, China; Key Laboratory of Chemistry and Engineering of Forest Products, State Ethnic Affairs Commission, Nanning 530006, China; Guangxi Key Laboratory of Chemistry and Engineering of Forest Products, Nanning 530006, China; Guangxi Collaborative Innovation Center for Chemistry and Engineering of Forest Products, Nanning 530006, China; Key Laboratory of Guangxi Colleges and Universities for Food Safety and Pharmaceutical Analytical Chemistry, Nanning 530006, China. Electronic address:
The low conductivity of many traditional metal-organic-framework (MOF)-based electrode limits their developments in the field of electrochemical energy storage and still of great challenge. The controllable preparation of various kinds of nanomaterials using thiol-functionalized MOF shows great prospects. In this work, a thiol-functionalized metal-organic framework sheet structure (Co-MOF/NF) on nickel foam was successfully prepared by in situ interfacial growth synthesis, which was transformed into its derivatives S-doped β-Co(OH) nanoflowers Co-x/NF (x = 1, 2 and 6) in different concentrations of KOH solutions through ion etching/exchange reaction.
View Article and Find Full Text PDFEngineered Amine-Functionalized Metal-Organic Framework to Fabricate a Composite for Next-Generation Asymmetric Supercapacitors with Ultrahigh Performance: Modulating the Energy Storage Barrier.
Langmuir
October 2024
Functional Inorganic Materials Lab (FIML), Department of Chemistry, Aligarh Muslim University, Aligarh 202002, India.
The present work summarizes the fabrication of an amine-functionalized cadmium-based metal-organic framework (MOF), {[Cd(AT)(BP)]·4DMF} or , by adopting a simple solvothermal approach using 2-aminoterephthalic acid (AT) as the main linker, while 4,4'-bipyridyl (BP) as an auxiliary linker. The structure of was validated by the single-crystal X-ray diffraction technique that revealed the formation of an overall three-dimensional network with BP acting as a bridge between the 2D sheets of the MOF. The robust framework of decorated with a free amine functional group was utilized for energy storage application.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!