RAD-54.L is required for the repair of meiotic double-strand DNA breaks (DSBs), playing an essential role in promoting removal of recombinase RAD-51 and normal completion of meiotic recombination. Failure to complete meiotic DSB repair leads to 100% lethality of embryos produced by null mutant mothers. Here we report a new partial loss of function allele, , that may prove useful for investigating meiotic mechanisms by providing a sensitized genetic background that reduces but does not eliminate the essential functions of RAD-54.L.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9561903 | PMC |
| http://dx.doi.org/10.17912/micropub.biology.000637 | DOI Listing |
Publication Analysis
Top Keywords
partial loss
8
loss function
8
function allele
8
allele rad-54l
4
rad-54l required
4
required repair
4
meiotic
4
repair meiotic
4
meiotic double-strand
4
double-strand dna
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!