might lower serum triglyceride levels colonic microbiota modulation and SCFA-mediated fat metabolism in parenteral tissues of growing-finishing pigs.

Gut microbiota and its metabolites play a key role in host metabolism. Our previous study found supplemental affected lipid metabolism of pigs, however, the underlying mechanism is unclear. In this study, we investigated the effects of on colonic bacteria composition and its metabolites, serum lipids and hormone levels, fat metabolism related enzyme activity and gene expression in various tissues of growing-finishing pigs. Twelve pigs were randomly distributed into two groups ( = 6), and pigs in each group were fed diets with (Con + LD) or without (Con) 0.1 % for 28 days. Results exhibited the deceased triglyceride (TG) levels and elevated free fatty acid (FFA) contents in serum and increased concentrations of butyric acid in colonic digesta after supplementation. Dietary increased abundance of and and tended to increase abundance of in colonic digesta. consumption up-regulated glucagon-like peptide1 (), monocarboxylate transporter1 ( and sodium-dependent monocarboxylate transporter1 () expression in colonic tissue. Administration of tended to increase lipoprotein lipase (LPL) activity, up-regulated , angiopoietin-like protein 4 (), and triglyceride hydrolase () expression and down-regulated fatty acid synthetase (), G protein-coupled receptor 41() and expression in the liver. addition increased adenosine monophosphate activated protein kinase () expression in , upregulated and cluster of differentiation 36 () expression in subcutaneous fat, and enhanced , adipocyte determination and differentiation-dependent factor 1 () and hormone sensitive lipase () expression in leaf lard. These findings suggested that might enhance lipolysis and fatty acid β-oxidation to lower serum TG levels via colonic microbiota modulation and short chain fatty acids-mediated lipid metabolism of growing-finishing pigs.