This study aimed to evaluate the antibacterial activity of isopropoxy benzene guanidine (IBG) against based on pharmacokinetics/pharmacodynamics (PK/PD) modeling in broilers. The PK parameters of IBG in the plasma and ileal content of -infected broilers following oral administration at 2, 30, and 60 mg/kg body weight were investigated. PD studies were conducted over oral administration ranging from 2 to 60 mg/kg and repeated every 12 h for 3 days. The inhibitory model was used for PK/PD modeling. Results showed that the MIC of IBG against was 0.5-32 mg/L. After oral administration of IBG, the peak concentration ( ), maximum concentration time ( ), and area under the concentration-time curve (AUC) in ileal content of broilers were 10.97-1,036.64 mg/L, 2.39-4.27 h, and 38.31-4,266.77 mg·h/L, respectively. After integrating the PK and PD data, the AUC /MIC ratios needed for the bacteriostasis, bactericidal activity, and bacterial eradication were 4.00, 240.74, and 476.98 h, respectively. For dosage calculation, a dosage regimen of 12.98 mg/kg repeated every 12 h for 3 days was be therapeutically effective in broilers against with MIC ≤ 2 mg/L. In addition, IBG showed potent activity against , which may be responsible for cell membrane destruction. These results can facilitate the evaluation of the use of IBG in the treatment of intestinal diseases in broilers caused by .
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9557049 | PMC |
http://dx.doi.org/10.3389/fvets.2022.1004248 | DOI Listing |
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