Pharmacokinetics and pharmacodynamics of isopropoxy benzene guanidine against in an intestinal infection model.

Front Vet Sci

Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.

Published: September 2022

This study aimed to evaluate the antibacterial activity of isopropoxy benzene guanidine (IBG) against based on pharmacokinetics/pharmacodynamics (PK/PD) modeling in broilers. The PK parameters of IBG in the plasma and ileal content of -infected broilers following oral administration at 2, 30, and 60 mg/kg body weight were investigated. PD studies were conducted over oral administration ranging from 2 to 60 mg/kg and repeated every 12 h for 3 days. The inhibitory model was used for PK/PD modeling. Results showed that the MIC of IBG against was 0.5-32 mg/L. After oral administration of IBG, the peak concentration ( ), maximum concentration time ( ), and area under the concentration-time curve (AUC) in ileal content of broilers were 10.97-1,036.64 mg/L, 2.39-4.27 h, and 38.31-4,266.77 mg·h/L, respectively. After integrating the PK and PD data, the AUC /MIC ratios needed for the bacteriostasis, bactericidal activity, and bacterial eradication were 4.00, 240.74, and 476.98 h, respectively. For dosage calculation, a dosage regimen of 12.98 mg/kg repeated every 12 h for 3 days was be therapeutically effective in broilers against with MIC ≤ 2 mg/L. In addition, IBG showed potent activity against , which may be responsible for cell membrane destruction. These results can facilitate the evaluation of the use of IBG in the treatment of intestinal diseases in broilers caused by .

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9557049PMC
http://dx.doi.org/10.3389/fvets.2022.1004248DOI Listing

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