A PHP Error was encountered

Severity: Warning

Message: file_get_contents(https://...@pubfacts.com&api_key=b8daa3ad693db53b1410957c26c9a51b4908&a=1): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests

Filename: helpers/my_audit_helper.php

Line Number: 176

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 176
Function: file_get_contents

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 250
Function: simplexml_load_file_from_url

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3122
Function: getPubMedXML

File: /var/www/html/application/controllers/Detail.php
Line: 575
Function: pubMedSearch_Global

File: /var/www/html/application/controllers/Detail.php
Line: 489
Function: pubMedGetRelatedKeyword

File: /var/www/html/index.php
Line: 316
Function: require_once

DCD Liver Grafts Can Safely Be Used for Recipients With Grade I-II Portal Vein Thrombosis: A Multicenter Analysis. | LitMetric

AI Article Synopsis

  • - The study examines the outcomes of liver transplantation (LT) using donation after circulatory death (DCD) grafts in patients with portal vein thrombosis (PVT), finding that surgical complexity was increased, but no prior studies focused on this combination.
  • - Out of 771 DCD LTs performed between 2006 and 2020, 91 patients (11.8%) had PVT, with varying severity levels; the majority underwent a procedure to remove clots before transplantation.
  • - The results indicated no significant differences in early allograft dysfunction, primary nonfunction rates, or survival between patients with and without PVT, suggesting DCD liver grafts can be safely used in select PVT cases,

Article Abstract

Unlabelled: With donation after circulatory death (DCD) liver transplantation (LT), the goal of the recipient implantation procedure is to minimize surgical complexity to avoid a tenuous environment for an already marginal graft. The presence of portal vein thrombosis (PVT) at the time of LT adds surgical complexity, yet' to date, no studies have investigated the utilization of DCD liver grafts for patients with PVT.

Methods: All DCD LT performed at Mayo Clinic-Florida, Mayo Clinic-Arizona, and Mayo Clinic-Rochester from 2006 to 2020 were reviewed (N = 771). Patients with PVT at the time of transplant were graded using Yerdel classification. A 1:3 propensity match between patients with PVT and those without PVT was performed.

Results: A total of 91 (11.8%) patients with PVT undergoing DCD LT were identified. Grade I PVT was present in 62.6% of patients, grade II PVT in 27.5%, grade III in 8.8%, and grade 4 in 1.1%. At the time of LT, thromboendovenectomy was performed in 89 cases (97.8%). There was no difference in the rates of early allograft dysfunction (43.2% versus 52.4%; = 0.13) or primary nonfunction (1.1% versus 1.1%; = 0.41) between the DCD PVT and DCD without PVT groups, respectively. The rate of ischemic cholangiopathy was not significantly different between the DCD PVT (11.0%) and DCD without PVT groups (10.6%; = 0.92). Graft ( = 0.58) and patient survival ( = 0.08) were similar between the 2 groups. Graft survival at 1-, 3-, and 5-y was 89.9%, 84.5%, and 79.3% in the DCD PVT group.

Conclusions: In appropriately selected recipients with grades I-II PVT, DCD liver grafts can be utilized safely with excellent outcomes.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9553382PMC
http://dx.doi.org/10.1097/TXD.0000000000001392DOI Listing

Publication Analysis

Top Keywords

dcd pvt
20
dcd liver
16
pvt
13
liver grafts
12
patients pvt
12
dcd
11
portal vein
8
vein thrombosis
8
surgical complexity
8
pvt time
8

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!