Demand forecasting is a scientific and methodical assessment of future demand for a critical product.The effective Demand Forecast Model (DFM) enables pharmaceutical companies to be successful in the global market. The purpose of this research paper is to validate various shallow and deep neural network methods for demand forecasting, with the aim of recommending sales and marketing strategies based on the trend/seasonal effects of eight different groups of pharmaceutical products with different characteristics. The root mean squared error (RMSE) is used as the predictive accuracy of DFMs. This study also found that the mean RMSE value of the shallow neural network-based DFMs was 6.27 for all drug categories, which was lower than deep neural network models. According to the findings, DFMs based on shallow neural networks can effectively estimate future demand for pharmaceutical products.
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http://dx.doi.org/10.1007/s00521-022-07889-9 | DOI Listing |
Sci Rep
January 2025
Desautels Faculty of Management, McGill University, Montreal, QC, Canada.
Logistics serve as a vital link between production and consumption. The balanced allocation of logistics demand and resources can promote the harmonious development of the logistics system, thereby fostering regional economic growth. As a leading region in China's reform and opening-up, Guangdong Province has experienced high economic growth.
View Article and Find Full Text PDFJCO Glob Oncol
January 2025
Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, Canada.
Purpose: Asparaginase (ASN) is a critical component of pediatric ALL protocols. Until recently, ASN was available in three formulations: native Escherichia coli, PEGylated E. coli (PEG), and Erwinase, with native E.
View Article and Find Full Text PDFTree Physiol
January 2025
School of Natural Resources, Faculty of Geographical Science, Beijing Normal University, Beijing 100875, China.
Seasonal variations of nutrients in different organs are an essential strategy for temperate trees to maintain growth and function. The seasonal variations and variability (i.e.
View Article and Find Full Text PDFGenes Environ
January 2025
Department of Pharmaceutical Engineering, Faculty of Engineering, Sanyo-Onoda City University, 1-1-1, Daigaku-dori, Sanyo-Onoda City, 756-0884, Yamaguchi, Japan.
The number of alternatives to animal tests (non-animal test methods) for human health developed globally account for more than 40% of the test methods in the Organisation for Economic Co-operation and Development (OECD) Guidelines for the Testing of Chemicals (TGs). Within the TGs, the National Institute of Health Sciences (NIHS) has standardized 16 OECD TGs for human health, implemented four major revisions, and developed one test method for the International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use (ICH) S10 guidelines on photosafety. This review describes trends in the OECD and Japan that mainly focus on international standardizations of non-animal test methods for human health.
View Article and Find Full Text PDFTrends Endocrinol Metab
January 2025
Cellular and Molecular Biology Program, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Internal Medicine, Division of Gastroenterology and Hepatology, Michigan Medicine at the University of Michigan, Ann Arbor, MI 48109, USA; Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:
Mitochondria perform essential metabolic processes that sustain cellular bioenergetics and biosynthesis. In a recent article, Ryu et al. explored how mitochondria coordinate biochemical reactions with opposing redox demands within the same cell.
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