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Lactated Ringer's solution versus saline fluid resuscitation for reducing PROGRESSION TO moderate-to-severe acute pancreatitis: a systematic review and meta-analysis.
Int J Surg
March 2025
Department of Hepatobiliary surgery, The Affiliated Hospital of Southwest Medical University, Lu Zhou, China.
Background: Fluid resuscitation represents a pivotal early therapeutic intervention in the management of acute pancreatitis (AP), yet a consensus on the optimal fluid type remains elusive. The present study endeavors to elucidate the differential effects of lactated Ringer's solution (LR) and normal saline (NS) in the initial treatment of AP.
Methods: A comprehensive literature search was conducted through the PubMed, Embase, and Cochrane Central Register of Controlled Trials (CENTRAL) databases, spanning from inception until July 2024.
Clinical Predictors and Prevalence of Enteral Nutrition Intolerance in Acute Pancreatitis: An Updated Systematic Review and Meta-Analysis.
Nutrients
March 2025
Shanghai Key Laboratory of Pancreatic Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China.
Acute pancreatitis (AP) leads to severe inflammation and nutritional deficits, with 80% of severe cases experiencing critical protein loss. Timely enteral nutrition is essential for recovery. This study systematically reviews and analyzes the incidence and predictors of enteral nutrition intolerance (ENI) in AP patients.
View Article and Find Full Text PDFThymic stromal lymphopoietin contributes to endometriotic lesion proliferation and disease-associated inflammation.
J Immunol
February 2025
Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada.
Endometriosis is a chronic disorder in which endometrial-like tissue presents outside the uterus. Patients with endometriosis have been shown to exhibit aberrant immune responses within the lesion microenvironment and in circulation which contribute to the development of endometriosis. Thymic stromal lymphopoietin (TSLP) is an alarmin involved in cell proliferation and the induction of T helper 2 (Th2) inflammation in various diseases, such as asthma, atopic dermatitis, and pancreatic and breast cancer.
View Article and Find Full Text PDFA dynamic elastance-based protocol to guide intraoperative fluid management in major abdominal surgery: A randomised clinical trial.
Eur J Anaesthesiol
March 2025
From the Department of Anaesthesiology, Intensive Care and Emergency Medicine, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy (AR, PA, LC, LSM, BR, SC, EC, FP, CC, MA, LS, AMDA), the Department of Basic Biotechnological Science, Intensive and Peri-operative Clinics, Università Cattolica del Sacro Cuore, Rome, Italy (PA, CF, SA, MA, LA).
Background: Arterial hypotension during major surgery is related to postoperative complications and mortality. Both fluids and vasopressors increase blood pressure (BP) by inducing different physiological response. We devised a protocol which relies on dynamic arterial elastance (Eadyn) to guide BP optimisation during major abdominal surgery, and tested its effectiveness on tissue perfusion.
View Article and Find Full Text PDFMolecular KRAS ctDNA Predicts Metastases and Survival in Pancreatic Cancer: A Prospective Cohort Study.
Ann Surg Oncol
March 2025
Division of Hepatobiliary and Pancreas Surgery, Department of Surgery, Mayo Clinic, Rochester, MN, USA.
Background: Patients with pancreatic ductal adenocarcinoma (PDAC) commonly have occult metastatic dissemination and current standard staging methods have significant limitations in identifying these patients. A clinically available assay allows for the identification of mutant KRAS (mKRAS) circulating tumor DNA (ctDNA) from patient plasma and peritoneal fluid that may identify these patients and impact treatment decision making. We investigated the patterns of diagnostic and prognostic capabilities of mKRAS ctDNA in patients with localized PDAC.
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