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Background: Ruxolitinib cream has demonstrated anti-inflammatory and antipruritic activity and was well tolerated in a phase 3 study in patients aged 2-11 years with mild to moderate atopic dermatitis (AD).
Objective: This study examined the safety, tolerability, pharmacokinetics, efficacy, and quality of life (QoL) with ruxolitinib cream under maximum-use conditions and with longer-term use.
Methods: Eligible patients were aged 2-11 years with moderate to severe AD [Investigator's Global Assessment (IGA) score 3-4], and ≥ 35% affected body surface area (BSA).
[Assessing the health of working informal caregivers : Analysis of an employment survey using propensity score matching].
Z Gerontol Geriatr
January 2025
Kuratorium Deutsche Altershilfe gGmbH (KDA), Köln, Deutschland.
Background: The majority of people in need of care in Germany are cared for at home by relatives or other close individuals. Many informal caregivers are also in paid employment and face the challenge of juggling the demands of both areas of life. This can adversely affect the caregiver's own health.
View Article and Find Full Text PDFBackground: Male pattern baldness (MPB) is commonly associated with prostate diseases, both of which can significantly impact men's quality of life. However, the relationship and causality between them remain unclear. In this study, we investigated the causal relationship between the two.
View Article and Find Full Text PDFCrystallographic Customization of Zinc Anode for High Performance Aqueous Metal Batteries.
Nano Lett
January 2025
Key Laboratory of Physics and Technology for Advanced Batteries (Ministry of Education), College of Physics, Jilin University, Changchun 130012, PR China.
Aqueous zinc metal batteries (AZMBs) are an energy storage system that is expected to replace traditional lithium batteries. However, the practical application of AZMBs is hampered by some inherent drawbacks. Herein, an amino acid additive with a screening property is introduced.
View Article and Find Full Text PDFA Novel Homozygous Loss-of-Function Variant in GPR156 Delineates Non-syndromic Hearing Loss.
Biochem Genet
January 2025
Department of Dermatology, Yale University School of Medicine, New Haven, CT, USA.
Non-syndromic hearing loss (NSHL) is a genetically heterogeneous disorder accounting for almost 70% of the total congenital hearing loss. The implementation of rapid advanced sequencing methods has significantly contributed to the correct molecular diagnosis for several rare genetic disorders, including NHSL. Features of two probands with NHSL were clinically and genetically evaluated.
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