Seven previously undescribed alkaloids, crinamabilines A-G, two non-alkaloidal compounds, crinamabidiene and 6-phenylpiperonyl alcohol, two first naturally occurring alkaloids, 3-epibuphanisine and (+)-1β,2β-epoxy-epicrinine, together with nineteen known alkaloids, were isolated from the bulbs of Crinum × amabile Donn ex Ker Gawl. Their structures and absolute configurations were elucidated by NMR, MS and ECD spectroscopic techniques. Ungeremine displayed the most potent inhibitory activity against acetylcholinesterase (IC 0.21 μM), which was about 6-fold more active than the reference drug, galanthamine (IC 1.23 μM). Ungeremine also exhibited the strongest inhibitory activity against butyrylcholinesterase (IC 3.57 μM), which was comparable to galanthamine (IC 3.11 μM). The molecular docking studies were performed and were well in agreement with the experimental results.
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Alkaloids with cholinesterase inhibitory activities from the bulbs of Crinum × amabile Donn ex Ker Gawl.
Phytochemistry
January 2023
Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok, 10240, Thailand.
Seven previously undescribed alkaloids, crinamabilines A-G, two non-alkaloidal compounds, crinamabidiene and 6-phenylpiperonyl alcohol, two first naturally occurring alkaloids, 3-epibuphanisine and (+)-1β,2β-epoxy-epicrinine, together with nineteen known alkaloids, were isolated from the bulbs of Crinum × amabile Donn ex Ker Gawl. Their structures and absolute configurations were elucidated by NMR, MS and ECD spectroscopic techniques. Ungeremine displayed the most potent inhibitory activity against acetylcholinesterase (IC 0.
View Article and Find Full Text PDFAmabiloid A from Donn ex Ker Gawl.
Nat Prod Res
October 2021
Department of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmaceutical Sciences and Center of Excellence for Innovation in Chemistry, Naresuan University, Phitsanulok, Thailand.
A new alkaloid, amabiloid A () was isolated from along with eleven known compounds. Their structures were determined by 1D and 2D NMR spectroscopic data. In addition, the acetyl- and butyrylcholinesterase inhibitory activities of the isolated compounds were evaluated.
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