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Age, gender and body-mass-index relationships with in vivo CB receptor availability in healthy humans measured with [C]OMAR PET. | LitMetric

AI Article Synopsis

  • Brain cannabinoid 1 receptors (CB1Rs) are linked to important functions like appetite and mood, and this study examined their availability across age, gender, and BMI using a PET imaging technique.
  • The study involved 58 healthy participants and found that CB1R availability declines with age, particularly in certain brain regions, with significant differences between men and women.
  • Results also indicated that higher BMI negatively affects CB1R availability in women, and the findings highlight the need for further research using different imaging techniques to understand these variations better.

Article Abstract

Brain cannabinoid 1 receptors (CB1Rs) contribute importantly to the regulation of autonomic tone, appetite, mood and cognition. Inconsistent results have been reported from positron emission tomography (PET) studies using different radioligands to examine relationships between age, gender and body mass index (BMI) and CB1R availability in healthy individuals. In this study, we examined these variables in 58 healthy individuals (age range: 18-55 years; 44 male; BMI=27.01±5.56), the largest cohort of subjects studied to date using the CB1R PET ligand [C]OMAR. There was a significant decline in CB1R availability (V) with age in the pallidum, cerebellum and posterior cingulate. Adjusting for BMI, age-related decline in V remained significant in the posterior cingulate among males, and in the cerebellum among women. CB1R availability was higher in women compared to men in the thalamus, pallidum and posterior cingulate. Adjusting for age, CB1R availability negatively correlated with BMI in women but not men. These findings differ from those reported using [C]OMAR and other radioligands such as [F]FMPEP-d and [F]MK-9470. Although reasons for these seemingly divergent findings are unclear, the choice of PET radioligand and range of BMI in the current dataset may contribute to the observed differences. This study highlights the need for cross-validation studies using both [C]OMAR and [F]FMPEP-d within the same cohort of subjects.

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Source
http://dx.doi.org/10.1016/j.neuroimage.2022.119674DOI Listing

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